Pathogenic factors of vibrios with special emphasis on Vibrio vulnificus

Sumio Shinoda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bacteria of the genus Vibrio are normal habitants of the aquatic environment and play roles for biocontrole of aquatic ecosystem, but some species are believed to be human pathogens. These species can be classified into two groups according to the types of diseases they cause: the gastrointestinal infections and the extraintestinal infections. The pathogenic species produce various pathogenic factors including enterotoxin, hemolysin, cytotoxin, protease, siderophore, adhesive factor, and hemagglutinin. We studied various pathogenic factors of vibrios with special emphasis on protease and hemolysin of V. vulnificus. V. vulnificus is now recognized as being among the most rapidly fatal of human pathogens, although the infection is appeared in patients having underlying disease(s) such as liver dysfunction, alcoholic cirrhosis or haemochromatosis. V. vulnificus protease (VVP) is thought to be a major toxic factor causing skin damage in the patients having septicemia. VVP is a metalloprotease and degrades a number of biologically important proteins including elastin, fibrinogen, and plasma proteinase inhibitors of complement components. VVP causes skin damages through activation of the Factor XII-plasma kallikrein-kinin cascade and/or exocytotic histamine release from mast cells, and a haemorrhagic lesion through digestion of the vascular basement membrane. Thus, the protease is the most probable candidate for tissue damage and bacterial invasion during an infection. Pathogenic roles and functional mechanism of other factors including hemolysins of V. vulnificus and V. mimicus are also shown in this review article.

Original languageEnglish
Pages (from-to)531-547
Number of pages17
JournalYakugaku Zasshi
Volume125
Issue number7
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Vibrio vulnificus
Vibrio
Peptide Hydrolases
Hemolysin Proteins
Complement Inactivating Agents
Infection
Hemolysin Factors
Plasma Kallikrein
Factor XII
Siderophores
Alcoholic Liver Cirrhosis
Skin
Kinins
Hemochromatosis
Elastin
Gastrointestinal Diseases
Histamine Release
Poisons
Enterotoxins
Cytotoxins

Keywords

  • Hemolysin
  • Metalloprotease
  • Pathogenic vibrios
  • Vibrio vulnificus

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Pathogenic factors of vibrios with special emphasis on Vibrio vulnificus. / Shinoda, Sumio.

In: Yakugaku Zasshi, Vol. 125, No. 7, 07.2005, p. 531-547.

Research output: Contribution to journalArticle

Shinoda, Sumio. / Pathogenic factors of vibrios with special emphasis on Vibrio vulnificus. In: Yakugaku Zasshi. 2005 ; Vol. 125, No. 7. pp. 531-547.
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