Pathogenesis of Severe Liver Injury in Patients with Anorexia Nervosa: A Report of Two Cases and a Literature Review

Masahiro Sakata, Akinobu Takaki, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Tetsuya Yasunaka, Hideki Onishi, Hidenori Shiraha, Hiroyuki Okada

Research output: Contribution to journalArticlepeer-review

Abstract

Anorexia nervosa (AN) can cause severe protein energy malnutrition and the consequent development of various organ disorders. AN is known to cause hepatic complications. We report two cases of starvation and refeeding-induced liver injury in patients with AN, and review the literature on the hepatic complications of AN. Acute liver injury can be induced by both starvation and refeeding, although the underlying pathomechanisms and management of liver injury differ between these two conditions. Clinicians should carefully identify the clinical features to ensure an accurate diagnosis and appropriate management of these conditions.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalKurume Medical Journal
Volume67
Issue number2-3
DOIs
Publication statusPublished - 2020

Keywords

  • anorexia nervosa
  • hepatic complication
  • refeeding syndrome
  • starvation induced liver injury

ASJC Scopus subject areas

  • Medicine(all)

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