Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice

Soumik Barman, Hemanta Koley, Dhrubajyoti Nag, Sumio Shinoda, Gopinath Balakrish Nair, Yoshifumi Takeda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume58
Issue number8
DOIs
Publication statusPublished - Aug 2014

Keywords

  • Heat-killed Shigellae
  • Multivalent Shigella immunogen
  • Passive immunity
  • Shigella vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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  • Cite this

    Barman, S., Koley, H., Nag, D., Shinoda, S., Nair, G. B., & Takeda, Y. (2014). Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice. MICROBIOLOGY and IMMUNOLOGY, 58(8), 463-466. https://doi.org/10.1111/1348-0421.12164