Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice

Soumik Barman, Hemanta Koley, Dhrubajyoti Nag, Sumio Shinoda, Gopinath Balakrish Nair, Yoshifumi Takeda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalMicrobiology and Immunology
Volume58
Issue number8
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Shigella
Immunity
Hot Temperature
Shigella dysenteriae
Immunoglobulin A
Lipopolysaccharides
Immunoglobulin G
Serum
Serogroup

Keywords

  • Heat-killed Shigellae
  • Multivalent Shigella immunogen
  • Passive immunity
  • Shigella vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Medicine(all)

Cite this

Barman, S., Koley, H., Nag, D., Shinoda, S., Nair, G. B., & Takeda, Y. (2014). Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice. Microbiology and Immunology, 58(8), 463-466. https://doi.org/10.1111/1348-0421.12164

Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice. / Barman, Soumik; Koley, Hemanta; Nag, Dhrubajyoti; Shinoda, Sumio; Nair, Gopinath Balakrish; Takeda, Yoshifumi.

In: Microbiology and Immunology, Vol. 58, No. 8, 2014, p. 463-466.

Research output: Contribution to journalArticle

Barman, S, Koley, H, Nag, D, Shinoda, S, Nair, GB & Takeda, Y 2014, 'Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice', Microbiology and Immunology, vol. 58, no. 8, pp. 463-466. https://doi.org/10.1111/1348-0421.12164
Barman, Soumik ; Koley, Hemanta ; Nag, Dhrubajyoti ; Shinoda, Sumio ; Nair, Gopinath Balakrish ; Takeda, Yoshifumi. / Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice. In: Microbiology and Immunology. 2014 ; Vol. 58, No. 8. pp. 463-466.
@article{c04fbb2f034f4e25bd9a201ffcba7673,
title = "Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice",
abstract = "The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.",
keywords = "Heat-killed Shigellae, Multivalent Shigella immunogen, Passive immunity, Shigella vaccine",
author = "Soumik Barman and Hemanta Koley and Dhrubajyoti Nag and Sumio Shinoda and Nair, {Gopinath Balakrish} and Yoshifumi Takeda",
year = "2014",
doi = "10.1111/1348-0421.12164",
language = "English",
volume = "58",
pages = "463--466",
journal = "Microbiology and Immunology",
issn = "0385-5600",
publisher = "Center for Academic Publications Japan",
number = "8",

}

TY - JOUR

T1 - Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice

AU - Barman, Soumik

AU - Koley, Hemanta

AU - Nag, Dhrubajyoti

AU - Shinoda, Sumio

AU - Nair, Gopinath Balakrish

AU - Takeda, Yoshifumi

PY - 2014

Y1 - 2014

N2 - The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.

AB - The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.

KW - Heat-killed Shigellae

KW - Multivalent Shigella immunogen

KW - Passive immunity

KW - Shigella vaccine

UR - http://www.scopus.com/inward/record.url?scp=84905221295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905221295&partnerID=8YFLogxK

U2 - 10.1111/1348-0421.12164

DO - 10.1111/1348-0421.12164

M3 - Article

C2 - 24909404

AN - SCOPUS:84905221295

VL - 58

SP - 463

EP - 466

JO - Microbiology and Immunology

JF - Microbiology and Immunology

SN - 0385-5600

IS - 8

ER -