Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice

Soumik Barman, Hemanta Koley, Dhrubajyoti Nag, Sumio Shinoda, Gopinath Balakrish Nair, Yoshifumi Takeda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
Issue number8
Publication statusPublished - Aug 2014


  • Heat-killed Shigellae
  • Multivalent Shigella immunogen
  • Passive immunity
  • Shigella vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


Dive into the research topics of 'Passive immunity with multi-serotype heat-killed Shigellae in neonatal mice'. Together they form a unique fingerprint.

Cite this