Participation of histamine H3 receptors in experimental allergic rhinitis of mice

Emiko Yokota, Shoji Kuyama, Yukio Sugimoto, Masami Ogawa, Chiaki Kamei

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H3-receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H1-receptor antagonist, cetirizine. Furthermore, simultaneous use of H3-receptor agonists, Sch 50971 or imetit, and an H1-receptor antagonist, cetirizine, caused a significant inhibitory effect on nasal symptoms at doses that showed no effect when used separately. The number of eosinophils in the nasal mucosa of mice sensitized with antigen was significantly decreased by cetirizine; however, Sch 50971 and imetit had no effect on eosinophil infiltration. These results clearly indicate that H 3 receptors are involved in the etiology of nasal allergy, and the stimulation of H3 receptors may be useful as a novel therapeutic approach in nasal allergy.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalJournal of Pharmacological Sciences
Volume108
Issue number2
DOIs
Publication statusPublished - 2008

Fingerprint

Histamine H3 Receptors
Nose
Cetirizine
Histamine Agonists
Histamine H1 Receptors
Antigens
Eosinophils
Hypersensitivity
Sneezing
Nasal Mucosa
Oral Administration
Allergic Rhinitis
4-(4-methyl-3-pyrrolidinyl)-1H-imidazole dihydrochloride
imetit

Keywords

  • Allergic rhinitis
  • Cetirizine
  • Eosinophil infiltration
  • Histamine H receptor
  • Histamine H-receptor agonist

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Participation of histamine H3 receptors in experimental allergic rhinitis of mice. / Yokota, Emiko; Kuyama, Shoji; Sugimoto, Yukio; Ogawa, Masami; Kamei, Chiaki.

In: Journal of Pharmacological Sciences, Vol. 108, No. 2, 2008, p. 206-211.

Research output: Contribution to journalArticle

Yokota, Emiko ; Kuyama, Shoji ; Sugimoto, Yukio ; Ogawa, Masami ; Kamei, Chiaki. / Participation of histamine H3 receptors in experimental allergic rhinitis of mice. In: Journal of Pharmacological Sciences. 2008 ; Vol. 108, No. 2. pp. 206-211.
@article{49f795edd7b44502be891359a8d21840,
title = "Participation of histamine H3 receptors in experimental allergic rhinitis of mice",
abstract = "The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H3-receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H1-receptor antagonist, cetirizine. Furthermore, simultaneous use of H3-receptor agonists, Sch 50971 or imetit, and an H1-receptor antagonist, cetirizine, caused a significant inhibitory effect on nasal symptoms at doses that showed no effect when used separately. The number of eosinophils in the nasal mucosa of mice sensitized with antigen was significantly decreased by cetirizine; however, Sch 50971 and imetit had no effect on eosinophil infiltration. These results clearly indicate that H 3 receptors are involved in the etiology of nasal allergy, and the stimulation of H3 receptors may be useful as a novel therapeutic approach in nasal allergy.",
keywords = "Allergic rhinitis, Cetirizine, Eosinophil infiltration, Histamine H receptor, Histamine H-receptor agonist",
author = "Emiko Yokota and Shoji Kuyama and Yukio Sugimoto and Masami Ogawa and Chiaki Kamei",
year = "2008",
doi = "10.1254/jphs.08164FP",
language = "English",
volume = "108",
pages = "206--211",
journal = "Journal of Pharmacological Sciences",
issn = "1347-8648",
publisher = "The Japanese Pharmacological Society",
number = "2",

}

TY - JOUR

T1 - Participation of histamine H3 receptors in experimental allergic rhinitis of mice

AU - Yokota, Emiko

AU - Kuyama, Shoji

AU - Sugimoto, Yukio

AU - Ogawa, Masami

AU - Kamei, Chiaki

PY - 2008

Y1 - 2008

N2 - The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H3-receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H1-receptor antagonist, cetirizine. Furthermore, simultaneous use of H3-receptor agonists, Sch 50971 or imetit, and an H1-receptor antagonist, cetirizine, caused a significant inhibitory effect on nasal symptoms at doses that showed no effect when used separately. The number of eosinophils in the nasal mucosa of mice sensitized with antigen was significantly decreased by cetirizine; however, Sch 50971 and imetit had no effect on eosinophil infiltration. These results clearly indicate that H 3 receptors are involved in the etiology of nasal allergy, and the stimulation of H3 receptors may be useful as a novel therapeutic approach in nasal allergy.

AB - The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor. Repeated topical application of antigen caused an increase in sneezing and nasal rubbing in sensitized mice. Oral administration of Sch 50971 and imetit, specific H3-receptor agonists, resulted in an inhibition of nasal symptoms induced by an antigen similar to an H1-receptor antagonist, cetirizine. Furthermore, simultaneous use of H3-receptor agonists, Sch 50971 or imetit, and an H1-receptor antagonist, cetirizine, caused a significant inhibitory effect on nasal symptoms at doses that showed no effect when used separately. The number of eosinophils in the nasal mucosa of mice sensitized with antigen was significantly decreased by cetirizine; however, Sch 50971 and imetit had no effect on eosinophil infiltration. These results clearly indicate that H 3 receptors are involved in the etiology of nasal allergy, and the stimulation of H3 receptors may be useful as a novel therapeutic approach in nasal allergy.

KW - Allergic rhinitis

KW - Cetirizine

KW - Eosinophil infiltration

KW - Histamine H receptor

KW - Histamine H-receptor agonist

UR - http://www.scopus.com/inward/record.url?scp=55549087239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55549087239&partnerID=8YFLogxK

U2 - 10.1254/jphs.08164FP

DO - 10.1254/jphs.08164FP

M3 - Article

VL - 108

SP - 206

EP - 211

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8648

IS - 2

ER -