Abstract
The purpose of this study was to investigate the involvement of chemical mediators other than histamine in nasal allergic signs using histamine H1 receptor-deficient mice. In passively sensitized mice, antigen instillation into the nasal cavity induced significant increases in sneezing and nasal rubbing in wild-type mice, but no such increases were observed in histamine H1 receptor-deficient mice. In actively sensitized mice, both sneezing and nasal rubbing were also significantly increased in a dose-dependent manner in both wild-type and histamine H1 receptor-deficient mice. Histamine H1 receptor antagonists such as cetirizine and epinastine significantly inhibited antigen-induced nasal allergic signs in wild-type mice, although the effects were incomplete. In addition, the thromboxane A2 receptor antagonist ramatroban also inhibited these responses in wild-type mice. However, the leukotriene receptor antagonist zafirlukast showed no effects in wild-type mice. These results suggested that in the acute allergic model (passive sensitization), only histamine H1 receptors are related to nasal signs induced by antigen, whereas in the chronic allergic model (active sensitization), both histamine H1 receptors and thromboxane A2 receptors were involved in the responses.
| Original language | English |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 449 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 9 2002 |
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Keywords
- Leukotriene
- Nasal allergic sign
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Participation of chemical mediators other than histamine in nasal allergy signs : A study using mice lacking histamine H1 receptors. / Kayasuga, Ryoji; Sugimoto, Yukio; Watanabe, Takeshi; Kamei, Chiaki.
In: European Journal of Pharmacology, Vol. 449, No. 3, 09.08.2002, p. 287-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Participation of chemical mediators other than histamine in nasal allergy signs
T2 - A study using mice lacking histamine H1 receptors
AU - Kayasuga, Ryoji
AU - Sugimoto, Yukio
AU - Watanabe, Takeshi
AU - Kamei, Chiaki
PY - 2002/8/9
Y1 - 2002/8/9
N2 - The purpose of this study was to investigate the involvement of chemical mediators other than histamine in nasal allergic signs using histamine H1 receptor-deficient mice. In passively sensitized mice, antigen instillation into the nasal cavity induced significant increases in sneezing and nasal rubbing in wild-type mice, but no such increases were observed in histamine H1 receptor-deficient mice. In actively sensitized mice, both sneezing and nasal rubbing were also significantly increased in a dose-dependent manner in both wild-type and histamine H1 receptor-deficient mice. Histamine H1 receptor antagonists such as cetirizine and epinastine significantly inhibited antigen-induced nasal allergic signs in wild-type mice, although the effects were incomplete. In addition, the thromboxane A2 receptor antagonist ramatroban also inhibited these responses in wild-type mice. However, the leukotriene receptor antagonist zafirlukast showed no effects in wild-type mice. These results suggested that in the acute allergic model (passive sensitization), only histamine H1 receptors are related to nasal signs induced by antigen, whereas in the chronic allergic model (active sensitization), both histamine H1 receptors and thromboxane A2 receptors were involved in the responses.
AB - The purpose of this study was to investigate the involvement of chemical mediators other than histamine in nasal allergic signs using histamine H1 receptor-deficient mice. In passively sensitized mice, antigen instillation into the nasal cavity induced significant increases in sneezing and nasal rubbing in wild-type mice, but no such increases were observed in histamine H1 receptor-deficient mice. In actively sensitized mice, both sneezing and nasal rubbing were also significantly increased in a dose-dependent manner in both wild-type and histamine H1 receptor-deficient mice. Histamine H1 receptor antagonists such as cetirizine and epinastine significantly inhibited antigen-induced nasal allergic signs in wild-type mice, although the effects were incomplete. In addition, the thromboxane A2 receptor antagonist ramatroban also inhibited these responses in wild-type mice. However, the leukotriene receptor antagonist zafirlukast showed no effects in wild-type mice. These results suggested that in the acute allergic model (passive sensitization), only histamine H1 receptors are related to nasal signs induced by antigen, whereas in the chronic allergic model (active sensitization), both histamine H1 receptors and thromboxane A2 receptors were involved in the responses.
KW - Leukotriene
KW - Nasal allergic sign
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UR - http://www.scopus.com/inward/citedby.url?scp=0037047675&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(02)02005-8
DO - 10.1016/S0014-2999(02)02005-8
M3 - Article
C2 - 12167471
AN - SCOPUS:0037047675
VL - 449
SP - 287
EP - 291
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -