Paroxysmal hypertension induced by an insulinoma

Research output: Contribution to journalArticle

Abstract

Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible etiology of hypertension induced by an insulinoma is catecholamine release in response to hypoglycemia, which may cause acute hypertension through activation of the sympatho-adrenal system. This case implies that sustained hyperinsulinemia due to insulinoma can be functionally linked to the induction of paroxysmal hypertension.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalInternal Medicine
Volume56
Issue number4
DOIs
Publication statusPublished - 2017

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Insulinoma
Hypertension
Hypoglycemia
Neuroendocrine Tumors
Hyperinsulinism
Catecholamines

Keywords

  • Hypertension
  • Hypoglycemia
  • Insulinoma

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Paroxysmal hypertension induced by an insulinoma",
abstract = "Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible etiology of hypertension induced by an insulinoma is catecholamine release in response to hypoglycemia, which may cause acute hypertension through activation of the sympatho-adrenal system. This case implies that sustained hyperinsulinemia due to insulinoma can be functionally linked to the induction of paroxysmal hypertension.",
keywords = "Hypertension, Hypoglycemia, Insulinoma",
author = "Ko Harada and Yoshihisa Hanayama and Kou Hasegawa and Masaya Iwamuro and Hideharu Hagiya and Ryuichi Yoshida and Fumio Otsuka",
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AU - Harada, Ko

AU - Hanayama, Yoshihisa

AU - Hasegawa, Kou

AU - Iwamuro, Masaya

AU - Hagiya, Hideharu

AU - Yoshida, Ryuichi

AU - Otsuka, Fumio

PY - 2017

Y1 - 2017

N2 - Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible etiology of hypertension induced by an insulinoma is catecholamine release in response to hypoglycemia, which may cause acute hypertension through activation of the sympatho-adrenal system. This case implies that sustained hyperinsulinemia due to insulinoma can be functionally linked to the induction of paroxysmal hypertension.

AB - Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible etiology of hypertension induced by an insulinoma is catecholamine release in response to hypoglycemia, which may cause acute hypertension through activation of the sympatho-adrenal system. This case implies that sustained hyperinsulinemia due to insulinoma can be functionally linked to the induction of paroxysmal hypertension.

KW - Hypertension

KW - Hypoglycemia

KW - Insulinoma

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