TY - JOUR
T1 - Parkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting
T2 - Basic and clinical studies
AU - Date, Isao
PY - 1996/1/1
Y1 - 1996/1/1
N2 - Neural transplantation is one of the promising approaches for the treatment of Parkinson's disease. Although the strategy of using adrenal medulla as donor tissue, rather than fetal nigra tissue, started as an alternative method, recent experimental studies demonstrated the efficacy of adrenal medulla grafting as a neurotrophic source. Many methods to increase the survival of grafted chromaffin cells have been developed, some of which have already been applied clinically with encouraging results. This review summarizes the advancements of adrenal medulla grafting in basic and clinical studies. Special attention is focused on the relationship with neurotrophic factors and how we can enhance the survival of grafted chromaffin cells.
AB - Neural transplantation is one of the promising approaches for the treatment of Parkinson's disease. Although the strategy of using adrenal medulla as donor tissue, rather than fetal nigra tissue, started as an alternative method, recent experimental studies demonstrated the efficacy of adrenal medulla grafting as a neurotrophic source. Many methods to increase the survival of grafted chromaffin cells have been developed, some of which have already been applied clinically with encouraging results. This review summarizes the advancements of adrenal medulla grafting in basic and clinical studies. Special attention is focused on the relationship with neurotrophic factors and how we can enhance the survival of grafted chromaffin cells.
KW - Adrenal medulla
KW - Dopamine
KW - Neural transplantation
KW - Neurotrophic factor
UR - http://www.scopus.com/inward/record.url?scp=0029873607&partnerID=8YFLogxK
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U2 - 10.1016/0361-9230(96)00010-X
DO - 10.1016/0361-9230(96)00010-X
M3 - Review article
C2 - 8722748
AN - SCOPUS:0029873607
VL - 40
SP - 1
EP - 19
JO - Journal of Electrophysiological Techniques
JF - Journal of Electrophysiological Techniques
SN - 0361-9230
IS - 1
ER -