Abstract
Neural transplantation is one of the promising approaches for the treatment of Parkinson's disease. Although the strategy of using adrenal medulla as donor tissue, rather than fetal nigra tissue, started as an alternative method, recent experimental studies demonstrated the efficacy of adrenal medulla grafting as a neurotrophic source. Many methods to increase the survival of grafted chromaffin cells have been developed, some of which have already been applied clinically with encouraging results. This review summarizes the advancements of adrenal medulla grafting in basic and clinical studies. Special attention is focused on the relationship with neurotrophic factors and how we can enhance the survival of grafted chromaffin cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1-19 |
| Number of pages | 19 |
| Journal | Brain Research Bulletin |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1996 |
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Keywords
- Adrenal medulla
- Dopamine
- Neural transplantation
- Neurotrophic factor
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Parkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting : Basic and clinical studies. / Date, Isao.
In: Brain Research Bulletin, Vol. 40, No. 1, 1996, p. 1-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting
T2 - Basic and clinical studies
AU - Date, Isao
PY - 1996
Y1 - 1996
N2 - Neural transplantation is one of the promising approaches for the treatment of Parkinson's disease. Although the strategy of using adrenal medulla as donor tissue, rather than fetal nigra tissue, started as an alternative method, recent experimental studies demonstrated the efficacy of adrenal medulla grafting as a neurotrophic source. Many methods to increase the survival of grafted chromaffin cells have been developed, some of which have already been applied clinically with encouraging results. This review summarizes the advancements of adrenal medulla grafting in basic and clinical studies. Special attention is focused on the relationship with neurotrophic factors and how we can enhance the survival of grafted chromaffin cells.
AB - Neural transplantation is one of the promising approaches for the treatment of Parkinson's disease. Although the strategy of using adrenal medulla as donor tissue, rather than fetal nigra tissue, started as an alternative method, recent experimental studies demonstrated the efficacy of adrenal medulla grafting as a neurotrophic source. Many methods to increase the survival of grafted chromaffin cells have been developed, some of which have already been applied clinically with encouraging results. This review summarizes the advancements of adrenal medulla grafting in basic and clinical studies. Special attention is focused on the relationship with neurotrophic factors and how we can enhance the survival of grafted chromaffin cells.
KW - Adrenal medulla
KW - Dopamine
KW - Neural transplantation
KW - Neurotrophic factor
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UR - http://www.scopus.com/inward/citedby.url?scp=0029873607&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(96)00010-X
DO - 10.1016/0361-9230(96)00010-X
M3 - Article
C2 - 8722748
AN - SCOPUS:0029873607
VL - 40
SP - 1
EP - 19
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
IS - 1
ER -