Parkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting: Basic and clinical studies

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Abstract

Neural transplantation is one of the promising approaches for the treatment of Parkinson's disease. Although the strategy of using adrenal medulla as donor tissue, rather than fetal nigra tissue, started as an alternative method, recent experimental studies demonstrated the efficacy of adrenal medulla grafting as a neurotrophic source. Many methods to increase the survival of grafted chromaffin cells have been developed, some of which have already been applied clinically with encouraging results. This review summarizes the advancements of adrenal medulla grafting in basic and clinical studies. Special attention is focused on the relationship with neurotrophic factors and how we can enhance the survival of grafted chromaffin cells.

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalBrain Research Bulletin
Volume40
Issue number1
DOIs
Publication statusPublished - 1996

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Chromaffin Cells
Adrenal Medulla
Parkinson Disease
Nerve Growth Factors
Fetus
Transplantation
Tissue Donors
Clinical Studies

Keywords

  • Adrenal medulla
  • Dopamine
  • Neural transplantation
  • Neurotrophic factor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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