Paretic Side/Normal Side Ratios of Cross-Sectional Areas of the Superior Oblique Muscle Vary Largely in Idiopathic Superior Oblique Palsy

Eriko Uchiyama, Toshihiko Matsuo, Sayuri Imai, Emi Itoshima

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: To search for a new definition of muscle hypoplasia in congenital or idiopathic superior oblique muscle palsy. Design: Retrospective case-control study. Methods: Cross-sectional areas of the superior oblique and 4 rectus muscles near the eye globe-optic nerve junction were measured by an image analysis software on magnetic resonance images of 50 patients with congenital or idiopathic superior oblique muscle palsy and 45 patients with other disease conditions serving as a control. The paretic side/contralateral normal side ratios of the cross-sectional areas and the left side/right side ratios were calculated for the superior oblique muscle palsy patients and the control patients, respectively. Results: The 95% confidence intervals in paretic side/contralateral side ratios of cross-sectional areas of the superior oblique muscle were 0.55 to 0.80 in the right-side superior oblique muscle palsy, and 0.48 to 0.75 in the left-side palsy, while the 95% confidence interval in the left side/right side ratios was 0.99 to 1.00 in the control. The 95% confidence intervals in the left side/right side ratios of the 4 rectus muscles were 1.00, both in the superior oblique muscle palsy and in the control. Conclusions: The muscle hypoplasia could be defined as such when the paretic side/contralateral side ratios of cross-sectional areas of the superior oblique muscle on magnetic resonance images fell outside the 95% confidence interval of the ratios in normal controls.

Original languageEnglish
Pages (from-to)508-512
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume149
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Oculomotor Muscles
Paralysis
Confidence Intervals
Muscles
Magnetic Resonance Spectroscopy
Optic Nerve
Case-Control Studies
Software

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Paretic Side/Normal Side Ratios of Cross-Sectional Areas of the Superior Oblique Muscle Vary Largely in Idiopathic Superior Oblique Palsy. / Uchiyama, Eriko; Matsuo, Toshihiko; Imai, Sayuri; Itoshima, Emi.

In: American Journal of Ophthalmology, Vol. 149, No. 3, 03.2010, p. 508-512.

Research output: Contribution to journalArticle

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abstract = "Purpose: To search for a new definition of muscle hypoplasia in congenital or idiopathic superior oblique muscle palsy. Design: Retrospective case-control study. Methods: Cross-sectional areas of the superior oblique and 4 rectus muscles near the eye globe-optic nerve junction were measured by an image analysis software on magnetic resonance images of 50 patients with congenital or idiopathic superior oblique muscle palsy and 45 patients with other disease conditions serving as a control. The paretic side/contralateral normal side ratios of the cross-sectional areas and the left side/right side ratios were calculated for the superior oblique muscle palsy patients and the control patients, respectively. Results: The 95{\%} confidence intervals in paretic side/contralateral side ratios of cross-sectional areas of the superior oblique muscle were 0.55 to 0.80 in the right-side superior oblique muscle palsy, and 0.48 to 0.75 in the left-side palsy, while the 95{\%} confidence interval in the left side/right side ratios was 0.99 to 1.00 in the control. The 95{\%} confidence intervals in the left side/right side ratios of the 4 rectus muscles were 1.00, both in the superior oblique muscle palsy and in the control. Conclusions: The muscle hypoplasia could be defined as such when the paretic side/contralateral side ratios of cross-sectional areas of the superior oblique muscle on magnetic resonance images fell outside the 95{\%} confidence interval of the ratios in normal controls.",
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