TY - JOUR
T1 - Parathyroid hormone-related protein as a potential tumor marker
T2 - A case report of ovarian clear cell carcinoma
AU - Suwaki, Naoko
AU - Masuyama, Hisashi
AU - Mizutani, Yasushi
AU - Kodama, Junichi
AU - Hiramatsu, Yuji
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Hypercalcemia is one of the important paraneoplastic syndromes, mostly occurring in patients with advanced cancer. Clear cell carcinoma is known to be one of the most common histological subtypes of ovarian tumor associated with hypercalcemia. We present a case of ovarian clear cell carcinoma with hypercalcemia caused by elevated serum parathyroid hormone-related protein (PTHrP). PTHrP mRNA and protein were detected by reverse transcription- polymerase chain reaction and immunohistochemical analysis in the primary and metastasis lesions. Serum calcium and PTHrP levels returned to normal after antihypercalcemic treatment and a radical operation, but they elevated along with the recurrence. Because tumor markers such as carcinoembryonic antigen, carbohydrate antigen (CA)125 and CA19-9 were unstable owing to the patient's liver cirrhosis and were not reliable data for management, serum calcium and PTHrP levels are shown to have been a potential indicator of the recurrence in this case.
AB - Hypercalcemia is one of the important paraneoplastic syndromes, mostly occurring in patients with advanced cancer. Clear cell carcinoma is known to be one of the most common histological subtypes of ovarian tumor associated with hypercalcemia. We present a case of ovarian clear cell carcinoma with hypercalcemia caused by elevated serum parathyroid hormone-related protein (PTHrP). PTHrP mRNA and protein were detected by reverse transcription- polymerase chain reaction and immunohistochemical analysis in the primary and metastasis lesions. Serum calcium and PTHrP levels returned to normal after antihypercalcemic treatment and a radical operation, but they elevated along with the recurrence. Because tumor markers such as carcinoembryonic antigen, carbohydrate antigen (CA)125 and CA19-9 were unstable owing to the patient's liver cirrhosis and were not reliable data for management, serum calcium and PTHrP levels are shown to have been a potential indicator of the recurrence in this case.
KW - Clear cell carcinoma
KW - Hypercalcemia
KW - Ovarian cancer
KW - Parathyroid hormone-related protein
UR - http://www.scopus.com/inward/record.url?scp=33645217341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645217341&partnerID=8YFLogxK
U2 - 10.1111/j.1447-0756.2006.00358.x
DO - 10.1111/j.1447-0756.2006.00358.x
M3 - Article
C2 - 16445533
AN - SCOPUS:33645217341
SN - 1341-8076
VL - 32
SP - 94
EP - 98
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
IS - 1
ER -
