Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment

Masaru Kinomura, Noriaki Shimada, Mana Nishikawa, Kazuyoshi Omori, Tomoyasu Jo, Yasunori Ueda, Kenji Notohara, Riko Kitazawa, Sohei Kitazawa, Masaki Fukushima, Kenichiro Asano

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1 Citation (Scopus)

Abstract

A 68-year-old man was hospitalized and examined for renal impairment. A laboratory analysis showed hypercalcemia. Although the serum parathyroid hormone and serum 1-25(OH)2 vitamin D3 levels were not elevated, the serum parathyroid hormone-related peptide (PTHrP) level was increased. Immunoelectrophoresis of the urine and bone marrow aspiration indicated multiple myeloma (MM). He was diagnosed with the coexistence of cast nephropathy and light chain deposition disease by a renal biopsy. Notably, PTHrP expression was detected in the myeloma cells based on immunohistochemistry and in situ hybridization. It is therefore important to examine the PTHrP concentration in MM patients with hypercalcemia.

Original languageEnglish
Pages (from-to)3029-3033
Number of pages5
JournalInternal Medicine
Volume54
Issue number23
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Cast nephropathy
  • Light chain deposition disease
  • PTHrP

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Kinomura, M., Shimada, N., Nishikawa, M., Omori, K., Jo, T., Ueda, Y., Notohara, K., Kitazawa, R., Kitazawa, S., Fukushima, M., & Asano, K. (2015). Parathyroid hormone-related peptide-producing multiple myeloma and renal impairment. Internal Medicine, 54(23), 3029-3033. https://doi.org/10.2169/internalmedicine.54.5085