Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

Satoshi Suzuki, Glenn M. Eastwood, Michael Bailey, David Gattas, Peter Kruger, Manoj Saxena, John D. Santamaria, Rinaldo Bellomo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Introduction: In this study, we aimed to examine the association between paracetamol administration in the intensive care unit (ICU) and mortality in critically ill patients. Methods: We conducted a multicenter retrospective observational study in four ICUs. We obtained information on paracetamol use, body temperature, demographic, clinical and outcome data from each hospital's clinical information system and admissions and discharges database. We performed statistical analysis to assess the association between paracetamol administration and hospital mortality. Results: We studied 15,818 patients with 691,348 temperature measurements at 4 ICUs. Of these patients, 10,046 (64%) received at least 1g of paracetamol. Patients who received paracetamol had lower in-hospital mortality (10% vs. 20%, P

Original languageEnglish
Article number162
JournalCritical care (London, England)
Volume19
Issue number1
DOIs
Publication statusPublished - Apr 13 2015

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Acetaminophen
Critical Illness
Observational Studies
Retrospective Studies
Hospital Mortality
Hospital Information Systems
Therapeutics
Body Temperature
Intensive Care Units
Demography
Databases
Temperature
Mortality

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Paracetamol therapy and outcome of critically ill patients : a multicenter retrospective observational study. / Suzuki, Satoshi; Eastwood, Glenn M.; Bailey, Michael; Gattas, David; Kruger, Peter; Saxena, Manoj; Santamaria, John D.; Bellomo, Rinaldo.

In: Critical care (London, England), Vol. 19, No. 1, 162, 13.04.2015.

Research output: Contribution to journalArticle

Suzuki, Satoshi ; Eastwood, Glenn M. ; Bailey, Michael ; Gattas, David ; Kruger, Peter ; Saxena, Manoj ; Santamaria, John D. ; Bellomo, Rinaldo. / Paracetamol therapy and outcome of critically ill patients : a multicenter retrospective observational study. In: Critical care (London, England). 2015 ; Vol. 19, No. 1.
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