Pancreatic hepatoid carcinoma mimicking a solid pseudopapillary neoplasm: A challenging case on endoscopic ultrasound-guided fine-needle aspiration

Yutaka Akimoto, Hironari Kato, Kazuyuki Matsumoto, Ryo Harada, Shinsuke Oda, Soichiro Fushimi, Shou Mizukawa, Shuntaro Yabe, Daisuke Uchida, Hiroyuki Seki, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Takahito Yagi, Hiroyuki Okada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 59-year-old man was admitted to our hospital for treatment of a 45 mm pancreatic mass found during a medical examination. Endoscopic ultrasound-guided fine-needle aspiration cytology showed polygonal cells with pseudopapillary structures. The tumor cells were positive for nuclear/cytoplasmic β-catenin and CD10, and negative for chromogranin A. After a tentative diagnosis of a solid pseudopapillary neoplasm, middle pancreatectomy was performed. Histologically, polygonal cells with abundant eosinophilic cytoplasm formed in the trabeculae and were immunohistochemically positive for HepPar1 and protein induced by vitamin K absence or antagonist-II. The tumor was finally diagnosed to be pancreatic hepatoid carcinoma. No recurrence occurred for 12 months, even without adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)2405-2411
Number of pages7
JournalInternal Medicine
Volume55
Issue number17
DOIs
Publication statusPublished - 2016

Keywords

  • EUS-FNA
  • Hepatoid carcinoma
  • Pancreatic tumor
  • Solid-pseudopapillary neoplasm
  • β-catenin

ASJC Scopus subject areas

  • Internal Medicine

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