Palonosetron prevents highly emetogenic chemotherapy-induced nausea and vomiting in oral cancer patients

ORAL CANCER STUDY GROUP OF CHUGOKU-SHIKOKU

Research output: Contribution to journalArticle

Abstract

Background/Aim: To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. Patients and Methods: Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. Results: The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. Conclusion: Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases.

Original languageEnglish
Pages (from-to)6977-6981
Number of pages5
JournalAnticancer research
Volume37
Issue number12
DOIs
Publication statusPublished - 2017

Keywords

  • Antiemetic therapy
  • Chemotherapy
  • Nausea
  • Oral cancer
  • Palonosetron
  • Vomiting

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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