Palladium/copper-catalyzed sila-Sonogashira reactions of aryl iodides with alkynylsilanes via a direct C-Si bond activation

Yasushi Nishihara, Eiji Inoue, Daisuke Ogawa, Yoshiaki Okada, Shintaro Noyori, Kentaro Takagi

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The palladium-catalyzed cross-coupling reactions of aryl iodides with alkynylsilanes in the presence of a substoichiometric amount (50 mol %) of copper(I) chloride as an activator in DMF under strictly non-basic reaction conditions afford the corresponding unsymmetrical diarylethynes in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible.

Original languageEnglish
Pages (from-to)4643-4646
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number32
DOIs
Publication statusPublished - Aug 12 2009

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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