Abstract
A series of unsymmetrical diarylethynes have been synthesized by the copper-catalyzed cross-coupling reaction of alkynylboronates with aryl iodides in high to excellent yields under palladium-free conditions. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible with this reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 518-521 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 54 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Feb 6 2013 |
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Keywords
- Alkynylboronates
- Copper
- Sonogashira-Hagihara coupling
- Stephens-Castro reaction
- Suzuki-Miyaura coupling
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Palladium-free synthesis of unsymmetrical diarylethynes by cross-coupling reaction of alkynylboronates with aryl iodides catalyzed by CuCl. / Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi.
In: Tetrahedron Letters, Vol. 54, No. 6, 06.02.2013, p. 518-521.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Palladium-free synthesis of unsymmetrical diarylethynes by cross-coupling reaction of alkynylboronates with aryl iodides catalyzed by CuCl
AU - Ogawa, Daisuke
AU - Li, Jing
AU - Suetsugu, Masato
AU - Jiao, Jiao
AU - Iwasaki, Masayuki
AU - Nishihara, Yasushi
PY - 2013/2/6
Y1 - 2013/2/6
N2 - A series of unsymmetrical diarylethynes have been synthesized by the copper-catalyzed cross-coupling reaction of alkynylboronates with aryl iodides in high to excellent yields under palladium-free conditions. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible with this reaction.
AB - A series of unsymmetrical diarylethynes have been synthesized by the copper-catalyzed cross-coupling reaction of alkynylboronates with aryl iodides in high to excellent yields under palladium-free conditions. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible with this reaction.
KW - Alkynylboronates
KW - Copper
KW - Sonogashira-Hagihara coupling
KW - Stephens-Castro reaction
KW - Suzuki-Miyaura coupling
UR - http://www.scopus.com/inward/record.url?scp=84872046997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872046997&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2012.11.069
DO - 10.1016/j.tetlet.2012.11.069
M3 - Article
AN - SCOPUS:84872046997
VL - 54
SP - 518
EP - 521
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 6
ER -