Abstract
A series of unsymmetrical diarylethynes have been synthesized by the copper-catalyzed cross-coupling reaction of alkynylboronates with aryl iodides in high to excellent yields under palladium-free conditions. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible with this reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 518-521 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 54 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Feb 6 2013 |
Keywords
- Alkynylboronates
- Copper
- Sonogashira-Hagihara coupling
- Stephens-Castro reaction
- Suzuki-Miyaura coupling
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Ogawa, D., Li, J., Suetsugu, M., Jiao, J., Iwasaki, M., & Nishihara, Y. (2013). Palladium-free synthesis of unsymmetrical diarylethynes by cross-coupling reaction of alkynylboronates with aryl iodides catalyzed by CuCl. Tetrahedron Letters, 54(6), 518-521. https://doi.org/10.1016/j.tetlet.2012.11.069