Palladium-free synthesis of unsymmetrical diarylethynes by cross-coupling reaction of alkynylboronates with aryl iodides catalyzed by CuCl

Daisuke Ogawa, Jing Li, Masato Suetsugu, Jiao Jiao, Masayuki Iwasaki, Yasushi Nishihara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of unsymmetrical diarylethynes have been synthesized by the copper-catalyzed cross-coupling reaction of alkynylboronates with aryl iodides in high to excellent yields under palladium-free conditions. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible with this reaction.

Original languageEnglish
Pages (from-to)518-521
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number6
DOIs
Publication statusPublished - Feb 6 2013

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Cross Reactions
Palladium
Iodides
Bearings (structural)
Electrons
Copper
Substrates

Keywords

  • Alkynylboronates
  • Copper
  • Sonogashira-Hagihara coupling
  • Stephens-Castro reaction
  • Suzuki-Miyaura coupling

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Palladium-free synthesis of unsymmetrical diarylethynes by cross-coupling reaction of alkynylboronates with aryl iodides catalyzed by CuCl. / Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi.

In: Tetrahedron Letters, Vol. 54, No. 6, 06.02.2013, p. 518-521.

Research output: Contribution to journalArticle

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