Abstract
Boron delivery: C-H borylation at the ortho-position of aromatic compounds is promoted by the treatment of 2-phenylpyridine, or its derivatives, with 9-borabicyclo[3.3.1]nonane in the presence of a palladium catalyst. This reaction proceeds at room temperature and can be conducted without the palladium catalyst at higher temperatures. In both cases, the regioselectivity is controlled by Lewis acid-base interaction between the boron and nitrogen atoms.
| Original language | English |
|---|---|
| Pages (from-to) | 4431-4434 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Apr 15 2013 |
Keywords
- Lewis acid
- Lewis base
- borylation
- palladium
- regioselectivity
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Kuninobu, Y., Iwanaga, T., Omura, T., & Takai, K. (2013). Palladium-catalyzed ortho-selective C-H borylation of 2-phenylpyridine and its derivatives at room temperature. Angewandte Chemie - International Edition, 52(16), 4431-4434. https://doi.org/10.1002/anie.201210328