Palladium-Catalyzed Intramolecular Asymmetric Hydroamination of Alkynes

Léopold M. Lutete, Isao Kadota, Yoshinori Yamamoto

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

The Pd-catalyzed reaction of internal alkynes with tethered amino groups in the presence of PhCO2H and RENORPHOS as chiral phosphine ligand is reported. Various five- and six-membered nitrogen-containing heterocycles were obtained in good to high yield with moderate to high ee.

Original languageEnglish
Pages (from-to)1622-1623
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number6
Publication statusPublished - Feb 18 2004
Externally publishedYes

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phosphine
Alkynes
Palladium
Nitrogen
Ligands

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Palladium-Catalyzed Intramolecular Asymmetric Hydroamination of Alkynes. / Lutete, Léopold M.; Kadota, Isao; Yamamoto, Yoshinori.

In: Journal of the American Chemical Society, Vol. 126, No. 6, 18.02.2004, p. 1622-1623.

Research output: Contribution to journalArticle

Lutete, Léopold M. ; Kadota, Isao ; Yamamoto, Yoshinori. / Palladium-Catalyzed Intramolecular Asymmetric Hydroamination of Alkynes. In: Journal of the American Chemical Society. 2004 ; Vol. 126, No. 6. pp. 1622-1623.
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