Palladium-catalyzed denitrogenation reaction of 1,2,3-benzotriazin-4(3 H)-ones incorporating isocyanides

Tomoya Miura, Yui Nishida, Masao Morimoto, Motoshi Yamauchi, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

1,2,3-Benzotriazin-4(3H)-ones and 1,2,3,4-benzothiatriazine 1,1(2H)-dioxide reacted with isocyanides in the presence of a palladium catalyst to give 3-(imino)isoindolin-1-ones and 3-(imino)thiaisoindoline 1,1-dioxides, respectively, in high yield. An intermediate azapalladacycle was generated through denitrogenation of the triazine moiety, and an isocyanide was incorporated therein.

Original languageEnglish
Pages (from-to)1429-1431
Number of pages3
JournalOrganic Letters
Volume13
Issue number6
DOIs
Publication statusPublished - Mar 18 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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