TY - JOUR
T1 - Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides
AU - Fu, Liyan
AU - Chen, Qiang
AU - Wang, Zhenhua
AU - Nishihara, Yasushi
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020
Y1 - 2020
N2 - Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp2)-C(sp3) bond formation via a highly efficient decarbonylative process. The hemilabile bidentate ligand DPPE plays a crucial role for retardation of the undesired β-hydride elimination.
AB - Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp2)-C(sp3) bond formation via a highly efficient decarbonylative process. The hemilabile bidentate ligand DPPE plays a crucial role for retardation of the undesired β-hydride elimination.
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U2 - 10.1021/acs.orglett.0c00542
DO - 10.1021/acs.orglett.0c00542
M3 - Article
C2 - 32134273
AN - SCOPUS:85081648459
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
ER -