Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides

Liyan Fu; Qiang Chen; Zhenhua Wang; Yasushi Nishihara

doi:10.1021/acs.orglett.0c00542

Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides

Liyan Fu, Qiang Chen, Zhenhua Wang, Yasushi Nishihara

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp²)-C(sp³) bond formation via a highly efficient decarbonylative process. The hemilabile bidentate ligand DPPE plays a crucial role for retardation of the undesired β-hydride elimination.

Original language	English
Journal	ACS Applied Materials and Interfaces
DOIs	https://doi.org/10.1021/acs.orglett.0c00542
Publication status	Accepted/In press - 2020

ASJC Scopus subject areas

Materials Science(all)

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title = "Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides",

abstract = "Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp2)-C(sp3) bond formation via a highly efficient decarbonylative process. The hemilabile bidentate ligand DPPE plays a crucial role for retardation of the undesired β-hydride elimination.",

author = "Liyan Fu and Qiang Chen and Zhenhua Wang and Yasushi Nishihara",

note = "Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society.",

year = "2020",

doi = "10.1021/acs.orglett.0c00542",

language = "English",

journal = "ACS applied materials & interfaces",

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AU - Fu, Liyan

AU - Chen, Qiang

AU - Wang, Zhenhua

AU - Nishihara, Yasushi

PY - 2020

Y1 - 2020

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AB - Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp2)-C(sp3) bond formation via a highly efficient decarbonylative process. The hemilabile bidentate ligand DPPE plays a crucial role for retardation of the undesired β-hydride elimination.

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SN - 1944-8244

ER -

Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides

Abstract

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