Abstract
Palladium-catalyzed cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator in diethyl ether at room temperature under strictly non-basic conditions affords the diaryl ketones or chalcones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible.
Original language | English |
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Pages (from-to) | 2565-2571 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 69 |
Issue number | 12 |
DOIs | |
Publication status | Published - Mar 25 2013 |
Keywords
- Chalcones
- Copper
- Cross-coupling
- Ketones
- Palladium
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry