Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

Yasushi Nishihara, Daisuke Saito, Eiji Inoue, Yoshiaki Okada, Mikihiro Miyazaki, Yoshiaki Inoue, Kentaro Takagi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Alkynylboronates can be employed as a practical and versatile precursor for a variety of π-conjugated organic compounds. In the presence of Cu(I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions.

Original languageEnglish
Pages (from-to)306-308
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number2
DOIs
Publication statusPublished - Jan 13 2010

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Cross Reactions
Palladium
Organic compounds
Chlorides
Salts
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl. / Nishihara, Yasushi; Saito, Daisuke; Inoue, Eiji; Okada, Yoshiaki; Miyazaki, Mikihiro; Inoue, Yoshiaki; Takagi, Kentaro.

In: Tetrahedron Letters, Vol. 51, No. 2, 13.01.2010, p. 306-308.

Research output: Contribution to journalArticle

Nishihara, Yasushi ; Saito, Daisuke ; Inoue, Eiji ; Okada, Yoshiaki ; Miyazaki, Mikihiro ; Inoue, Yoshiaki ; Takagi, Kentaro. / Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl. In: Tetrahedron Letters. 2010 ; Vol. 51, No. 2. pp. 306-308.
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