Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease

Tetsuro Murakami, Mikio Shoji, Yuzuru Imai, Haruhisa Inoue, Takeshi Kawarabayashi, Etsuro Matsubara, Yasuo Harigaya, Atsushi Sasaki, Ryosuke Takahashi, Koji Abe

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

We examined the distribution of Pael-R, a newly identified substrate for Parkin, in Parkinson's disease (PD) and multiple system atrophy (MSA). Pael-R, Parkin, α-synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael-R was localized in the core of LBs. Parkin and α-synuclein accumulated in the halo, neuronal cell bodies, and processes. These findings potentially suggest the involvement of Pael-R in LB formation, and protection role of Parkin in Pael-R-mediated neurotoxicity in PD. The absence of Pael-R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs.

Original languageEnglish
Pages (from-to)439-442
Number of pages4
JournalAnnals of Neurology
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2004

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Lewy Bodies
Parkinson Disease
Synucleins
Multiple System Atrophy
Inclusion Bodies
Neuroglia
Neurites
Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Murakami, T., Shoji, M., Imai, Y., Inoue, H., Kawarabayashi, T., Matsubara, E., ... Abe, K. (2004). Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease. Annals of Neurology, 55(3), 439-442. https://doi.org/10.1002/ana.20064

Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease. / Murakami, Tetsuro; Shoji, Mikio; Imai, Yuzuru; Inoue, Haruhisa; Kawarabayashi, Takeshi; Matsubara, Etsuro; Harigaya, Yasuo; Sasaki, Atsushi; Takahashi, Ryosuke; Abe, Koji.

In: Annals of Neurology, Vol. 55, No. 3, 03.2004, p. 439-442.

Research output: Contribution to journalArticle

Murakami, T, Shoji, M, Imai, Y, Inoue, H, Kawarabayashi, T, Matsubara, E, Harigaya, Y, Sasaki, A, Takahashi, R & Abe, K 2004, 'Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease', Annals of Neurology, vol. 55, no. 3, pp. 439-442. https://doi.org/10.1002/ana.20064
Murakami T, Shoji M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E et al. Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease. Annals of Neurology. 2004 Mar;55(3):439-442. https://doi.org/10.1002/ana.20064
Murakami, Tetsuro ; Shoji, Mikio ; Imai, Yuzuru ; Inoue, Haruhisa ; Kawarabayashi, Takeshi ; Matsubara, Etsuro ; Harigaya, Yasuo ; Sasaki, Atsushi ; Takahashi, Ryosuke ; Abe, Koji. / Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease. In: Annals of Neurology. 2004 ; Vol. 55, No. 3. pp. 439-442.
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