Pael-R Is Accumulated in Lewy Bodies of Parkinson's Disease

Tetsuro Murakami, Mikio Shoji, Yuzuru Imai, Haruhisa Inoue, Takeshi Kawarabayashi, Etsuro Matsubara, Yasuo Harigaya, Atsushi Sasaki, Ryosuke Takahashi, Koji Abe

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

We examined the distribution of Pael-R, a newly identified substrate for Parkin, in Parkinson's disease (PD) and multiple system atrophy (MSA). Pael-R, Parkin, α-synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael-R was localized in the core of LBs. Parkin and α-synuclein accumulated in the halo, neuronal cell bodies, and processes. These findings potentially suggest the involvement of Pael-R in LB formation, and protection role of Parkin in Pael-R-mediated neurotoxicity in PD. The absence of Pael-R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs.

Original languageEnglish
Pages (from-to)439-442
Number of pages4
JournalAnnals of Neurology
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2004

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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