p53 and MDM2 expressionin oral squamous cell carcinoma

Tomohiro Matsumura, Yasuto Yoshihama, Takuji Kimura, Satoru Shintani, Rafael E. Alcalde

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31 % of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalOncology (Switzerland)
Volume53
Issue number4
DOIs
Publication statusPublished - Jan 1 1996

Keywords

  • Gene
  • Immunohistochemistry
  • Leukoplakia
  • Oral squamous cell carcinoma
  • Protein
  • p53 MDM2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Matsumura, T., Yoshihama, Y., Kimura, T., Shintani, S., & Alcalde, R. E. (1996). p53 and MDM2 expressionin oral squamous cell carcinoma. Oncology (Switzerland), 53(4), 308-312. https://doi.org/10.1159/000227578