p53 and MDM2 expression in oral squamous cell carcinoma

Tomohiro Matsumura, Yasuto Yoshihama, Takuji Kimura, Satoru Shintani, Rafael E. Alcalde

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31% of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalOncology
Volume53
Issue number4
Publication statusPublished - Jul 1996

Fingerprint

Squamous Cell Carcinoma
Proto-Oncogene Proteins c-mdm2
p53 Genes
Proto-Oncogenes
Tumor Suppressor Genes
Epithelium
Carcinoma
Mutation
Incidence
Genes
Neoplasms
Proteins

Keywords

  • Gene
  • Immunohistochemistry
  • Leukoplakia
  • MDM2
  • Oral squamous cell carcinoma
  • p53
  • Protein

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Matsumura, T., Yoshihama, Y., Kimura, T., Shintani, S., & Alcalde, R. E. (1996). p53 and MDM2 expression in oral squamous cell carcinoma. Oncology, 53(4), 308-312.

p53 and MDM2 expression in oral squamous cell carcinoma. / Matsumura, Tomohiro; Yoshihama, Yasuto; Kimura, Takuji; Shintani, Satoru; Alcalde, Rafael E.

In: Oncology, Vol. 53, No. 4, 07.1996, p. 308-312.

Research output: Contribution to journalArticle

Matsumura, T, Yoshihama, Y, Kimura, T, Shintani, S & Alcalde, RE 1996, 'p53 and MDM2 expression in oral squamous cell carcinoma', Oncology, vol. 53, no. 4, pp. 308-312.
Matsumura T, Yoshihama Y, Kimura T, Shintani S, Alcalde RE. p53 and MDM2 expression in oral squamous cell carcinoma. Oncology. 1996 Jul;53(4):308-312.
Matsumura, Tomohiro ; Yoshihama, Yasuto ; Kimura, Takuji ; Shintani, Satoru ; Alcalde, Rafael E. / p53 and MDM2 expression in oral squamous cell carcinoma. In: Oncology. 1996 ; Vol. 53, No. 4. pp. 308-312.
@article{1cc10ca7aace49eba4c50c27dd35461e,
title = "p53 and MDM2 expression in oral squamous cell carcinoma",
abstract = "The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40{\%} of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31{\%} of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.",
keywords = "Gene, Immunohistochemistry, Leukoplakia, MDM2, Oral squamous cell carcinoma, p53, Protein",
author = "Tomohiro Matsumura and Yasuto Yoshihama and Takuji Kimura and Satoru Shintani and Alcalde, {Rafael E.}",
year = "1996",
month = "7",
language = "English",
volume = "53",
pages = "308--312",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - p53 and MDM2 expression in oral squamous cell carcinoma

AU - Matsumura, Tomohiro

AU - Yoshihama, Yasuto

AU - Kimura, Takuji

AU - Shintani, Satoru

AU - Alcalde, Rafael E.

PY - 1996/7

Y1 - 1996/7

N2 - The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31% of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

AB - The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and is a frequent abnormality in oral squamous cell carcinoma and its precancerous lesions. MDM2 (murine double minute-2), a new proto-oncogene, may be associated with p53 gene products and may negatively affect the transcriptional activating function of p53. The purpose of this study was to investigate the incidence of MDM2 and its relationship to the expression of p53 in oral squamous cell carcinoma and precancerous lesions. Overexpression of p53 and MDM2 proteins was detected in 52 and 40% of oral squamous cell carcinomas, respectively. p53 gene mutation, absent in normal oral epithelium was observed in 31% of the carcinoma cases. Our findings suggested that MDM2 protein may be an alternative mechanism causing p53 protein dysfunction in oral squamous cell carcinoma.

KW - Gene

KW - Immunohistochemistry

KW - Leukoplakia

KW - MDM2

KW - Oral squamous cell carcinoma

KW - p53

KW - Protein

UR - http://www.scopus.com/inward/record.url?scp=0029882622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029882622&partnerID=8YFLogxK

M3 - Article

C2 - 8692535

AN - SCOPUS:0029882622

VL - 53

SP - 308

EP - 312

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 4

ER -