Oxytocin mediates the antidepressant effects of mating behavior in male mice

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13 Citations (Scopus)

Abstract

A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalNeuroscience Research
Volume68
Issue number2
DOIs
Publication statusPublished - Oct 2010

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Oxytocin
Antidepressive Agents
Depression
Oxytocin Receptors
Sexual Behavior
Central Nervous System

Keywords

  • Anxiety
  • Depression
  • Mating behavior
  • Oxytocin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Oxytocin mediates the antidepressant effects of mating behavior in male mice",
abstract = "A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.",
keywords = "Anxiety, Depression, Mating behavior, Oxytocin",
author = "Hiroaki Matsushita and Kazuhito Tomizawa and Naoki Okimoto and Tei-ichi Nishiki and Iori Ohmori and Hideki Matsui",
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AU - Matsushita, Hiroaki

AU - Tomizawa, Kazuhito

AU - Okimoto, Naoki

AU - Nishiki, Tei-ichi

AU - Ohmori, Iori

AU - Matsui, Hideki

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AB - A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.

KW - Anxiety

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