Oxytocin mediates the antidepressant effects of mating behavior in male mice

Hiroaki Matsushita; Kazuhito Tomizawa; Naoki Okimoto; Tei-ichi Nishiki; Iori Ohmori; Hideki Matsui

doi:10.1016/j.neures.2010.06.007

Oxytocin mediates the antidepressant effects of mating behavior in male mice

Hiroaki Matsushita, Kazuhito Tomizawa, Naoki Okimoto, Tei-ichi Nishiki, Iori Ohmori, Hideki Matsui

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.

Original language	English
Pages (from-to)	151-153
Number of pages	3
Journal	Neuroscience Research
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/j.neures.2010.06.007
Publication status	Published - Oct 2010

Keywords

Anxiety
Depression
Mating behavior
Oxytocin

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neures.2010.06.007

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title = "Oxytocin mediates the antidepressant effects of mating behavior in male mice",

abstract = "A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.",

keywords = "Anxiety, Depression, Mating behavior, Oxytocin",

author = "Hiroaki Matsushita and Kazuhito Tomizawa and Naoki Okimoto and Tei-ichi Nishiki and Iori Ohmori and Hideki Matsui",

note = "Funding Information: This work was supported by a Grant-in-aid for Scientific Research on Priority Areas-System study on higher-order brain functions from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by a Grant-in-aid for Scientific Research from the Ministry of Health, Labour and Welfare of Japan .",

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AU - Matsushita, Hiroaki

AU - Tomizawa, Kazuhito

AU - Okimoto, Naoki

AU - Nishiki, Tei-ichi

AU - Ohmori, Iori

AU - Matsui, Hideki

N1 - Funding Information: This work was supported by a Grant-in-aid for Scientific Research on Priority Areas-System study on higher-order brain functions from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by a Grant-in-aid for Scientific Research from the Ministry of Health, Labour and Welfare of Japan .

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Y1 - 2010/10

N2 - A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.

AB - A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior.

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KW - Depression

KW - Mating behavior

KW - Oxytocin

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Oxytocin mediates the antidepressant effects of mating behavior in male mice

Abstract

Keywords

ASJC Scopus subject areas

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