TY - JOUR
T1 - Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes
AU - Yamamoto, Ikuo
AU - Watanabe, Kazuhito
AU - Narimatsu, Shizuo
AU - Yoshimura, Hidetoshi
PY - 1988/6/16
Y1 - 1988/6/16
N2 - 11-Oxo-Δ8-tetrahydrocannabinol was oxidized to Δ8-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into Δ8-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.
AB - 11-Oxo-Δ8-tetrahydrocannabinol was oxidized to Δ8-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into Δ8-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.
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U2 - 10.1016/S0006-291X(88)81163-X
DO - 10.1016/S0006-291X(88)81163-X
M3 - Article
C2 - 2838024
AN - SCOPUS:0023927661
VL - 153
SP - 779
EP - 782
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -