Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes

Ikuo Yamamoto; Kazuhito Watanabe; Shizuo Narimatsu; Hidetoshi Yoshimura

doi:10.1016/S0006-291X(88)81163-X

Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes

Ikuo Yamamoto, Kazuhito Watanabe, Shizuo Narimatsu, Hidetoshi Yoshimura

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

11-Oxo-Δ⁸-tetrahydrocannabinol was oxidized to Δ⁸-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into Δ⁸-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.

Original language	English
Pages (from-to)	779-782
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	153
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(88)81163-X
Publication status	Published - Jun 16 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "11-Oxo-Δ8-tetrahydrocannabinol was oxidized to Δ8-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into Δ8-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.",

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AU - Yamamoto, Ikuo

AU - Watanabe, Kazuhito

AU - Narimatsu, Shizuo

AU - Yoshimura, Hidetoshi

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AB - 11-Oxo-Δ8-tetrahydrocannabinol was oxidized to Δ8-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into Δ8-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.

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