Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes

Ikuo Yamamoto, Kazuhito Watanabe, Shizuo Narimatsu, Hidetoshi Yoshimura

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

11-Oxo-Δ8-tetrahydrocannabinol was oxidized to Δ8-tetrahydrocannabinol-11-oic acid by mouse hepatic microsomes. The oxygenation mechanism in the reaction was confirmed by the incorporation of oxygen-18 from molecular oxygen into Δ8-tetrahydrocannabinol-11-oic acid. The oxygenation of aldehyde to carboxylic acid represents a novel mechanism in biological oxidation of aldehyde to carboxylic acid.

Original languageEnglish
Pages (from-to)779-782
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume153
Issue number2
DOIs
Publication statusPublished - Jun 16 1988
Externally publishedYes

Fingerprint

Dronabinol
Oxygenation
Xenobiotics
Carboxylic Acids
Microsomes
Aldehydes
Oxidation
Liver
Oxygen
Acids
Molecular oxygen

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes. / Yamamoto, Ikuo; Watanabe, Kazuhito; Narimatsu, Shizuo; Yoshimura, Hidetoshi.

In: Biochemical and Biophysical Research Communications, Vol. 153, No. 2, 16.06.1988, p. 779-782.

Research output: Contribution to journalArticle

Yamamoto, Ikuo ; Watanabe, Kazuhito ; Narimatsu, Shizuo ; Yoshimura, Hidetoshi. / Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes. In: Biochemical and Biophysical Research Communications. 1988 ; Vol. 153, No. 2. pp. 779-782.
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