TY - JOUR
T1 - Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme
AU - Watanabe, K.
AU - Narimatsu, S.
AU - Yamamoto, I.
AU - Yoshimura, H.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - The oxygenation of an aldehyde, 11-oxo-Δ8-tetrahydrocannabinol to a carboxylic acid, Δ8-tetrahydrocannabinol-11-oic acid was catalyzed by cytochrome P-450 MUT-2 purified from hepatic microsomes of male ddN mice. The oxygenation mechanism was confirmed by the incorporation of oxygen-18 from molecular oxygen into the carboxylic acid formed. An aldehyde form but not a hydrated form of 11-oxo-Δ8-tetrahydrocannabinol may be a substrate for the cytochrome P-450. The oxygenation of aldehyde catalyzed by cytochrome P-450 might be a common metabolic reaction in biological systems, and should be considered as an additional role of cytochrome P-450 in biotransformation of endogenous compounds and xenobiotics.
AB - The oxygenation of an aldehyde, 11-oxo-Δ8-tetrahydrocannabinol to a carboxylic acid, Δ8-tetrahydrocannabinol-11-oic acid was catalyzed by cytochrome P-450 MUT-2 purified from hepatic microsomes of male ddN mice. The oxygenation mechanism was confirmed by the incorporation of oxygen-18 from molecular oxygen into the carboxylic acid formed. An aldehyde form but not a hydrated form of 11-oxo-Δ8-tetrahydrocannabinol may be a substrate for the cytochrome P-450. The oxygenation of aldehyde catalyzed by cytochrome P-450 might be a common metabolic reaction in biological systems, and should be considered as an additional role of cytochrome P-450 in biotransformation of endogenous compounds and xenobiotics.
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M3 - Article
C2 - 1847130
AN - SCOPUS:0025907945
SN - 0021-9258
VL - 266
SP - 2709
EP - 2711
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 5
ER -