Oxygen supersaturated fluid using fine micro/nanobubbles

Noriaki Matsuki, Takuji Ishikawa, Shingo Ichiba, Naoki Shiba, Yoshihito Ujike, Takami Yamaguchi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.

Original languageEnglish
Pages (from-to)4495-4505
Number of pages11
JournalInternational Journal of Nanomedicine
Volume9
DOIs
Publication statusPublished - 2014

Fingerprint

Oxygen
Microbubbles
Fluids
Oxygenation
Gases
Intravenous Infusions
Sodium Chloride
Blood
Disease control
Electric charge
Dextran
Blood vessels
Infection Control
Dextrans
Free radicals
Drug delivery
Health care
Solubility
Free Radicals
Blood Vessels

Keywords

  • fine micro/nanobubble
  • fluid oxygenation
  • microbubble
  • nanobubble
  • oxygenation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matsuki, N., Ishikawa, T., Ichiba, S., Shiba, N., Ujike, Y., & Yamaguchi, T. (2014). Oxygen supersaturated fluid using fine micro/nanobubbles. International Journal of Nanomedicine, 9, 4495-4505. https://doi.org/10.2147/IJN.S68840

Oxygen supersaturated fluid using fine micro/nanobubbles. / Matsuki, Noriaki; Ishikawa, Takuji; Ichiba, Shingo; Shiba, Naoki; Ujike, Yoshihito; Yamaguchi, Takami.

In: International Journal of Nanomedicine, Vol. 9, 2014, p. 4495-4505.

Research output: Contribution to journalArticle

Matsuki, N, Ishikawa, T, Ichiba, S, Shiba, N, Ujike, Y & Yamaguchi, T 2014, 'Oxygen supersaturated fluid using fine micro/nanobubbles', International Journal of Nanomedicine, vol. 9, pp. 4495-4505. https://doi.org/10.2147/IJN.S68840
Matsuki N, Ishikawa T, Ichiba S, Shiba N, Ujike Y, Yamaguchi T. Oxygen supersaturated fluid using fine micro/nanobubbles. International Journal of Nanomedicine. 2014;9:4495-4505. https://doi.org/10.2147/IJN.S68840
Matsuki, Noriaki ; Ishikawa, Takuji ; Ichiba, Shingo ; Shiba, Naoki ; Ujike, Yoshihito ; Yamaguchi, Takami. / Oxygen supersaturated fluid using fine micro/nanobubbles. In: International Journal of Nanomedicine. 2014 ; Vol. 9. pp. 4495-4505.
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