Abstract
Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 4495-4505 |
| Number of pages | 11 |
| Journal | International Journal of Nanomedicine |
| Volume | 9 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- fine micro/nanobubble
- fluid oxygenation
- microbubble
- nanobubble
- oxygenation
ASJC Scopus subject areas
- Medicine(all)
Cite this
Oxygen supersaturated fluid using fine micro/nanobubbles. / Matsuki, Noriaki; Ishikawa, Takuji; Ichiba, Shingo; Shiba, Naoki; Ujike, Yoshihito; Yamaguchi, Takami.
In: International Journal of Nanomedicine, Vol. 9, 2014, p. 4495-4505.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxygen supersaturated fluid using fine micro/nanobubbles
AU - Matsuki, Noriaki
AU - Ishikawa, Takuji
AU - Ichiba, Shingo
AU - Shiba, Naoki
AU - Ujike, Yoshihito
AU - Yamaguchi, Takami
PY - 2014
Y1 - 2014
N2 - Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.
AB - Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.
KW - fine micro/nanobubble
KW - fluid oxygenation
KW - microbubble
KW - nanobubble
KW - oxygenation
UR - http://www.scopus.com/inward/record.url?scp=84929106825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929106825&partnerID=8YFLogxK
U2 - 10.2147/IJN.S68840
DO - 10.2147/IJN.S68840
M3 - Article
C2 - 25285003
AN - SCOPUS:84929106825
VL - 9
SP - 4495
EP - 4505
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
SN - 1176-9114
ER -