TY - JOUR
T1 - Oxygen saturation imaging as a useful tool for visualizing the mode of action of photodynamic therapy for esophageal cancer
AU - Suyama, Masayuki
AU - Yoda, Yusuke
AU - Yamamoto, Yoichi
AU - Sunakawa, Hironori
AU - Minamide, Tatsunori
AU - Hori, Keisuke
AU - Ikematsu, Hiroaki
AU - Yano, Tomonori
N1 - Funding Information:
Dr Yano receives research grant funding from FujiFilm. All other authors disclosed no financial relationships. OS imaging endoscopy system was provided by Fujifilm Corporation, Tokyo, Japan.
Funding Information:
A part of this study was supported by the National Cancer Center Research and Development Fund (29-A-10) of Japan. This lists individuals who have made important contributions without meeting authorship criteria. We thank all the patients, their families, the clinicians at this center, and the investigators who participated in this study. Technical support for medical devices was provided by T. Omori, T. Saito, K. Otani, Y. Yoshimori, N. Shigeta, T. Okamoto, and S. Ozawa of Fujifilm Corporation, Tokyo, Japan.
Funding Information:
A part of this study was supported by the National Cancer Center Research and Development Fund (29-A-10) of Japan. This lists individuals who have made important contributions without meeting authorship criteria. We thank all the patients, their families, the clinicians at this center, and the investigators who participated in this study. Technical support for medical devices was provided by T. Omori, T. Saito, K. Otani, Y. Yoshimori, N. Shigeta, T. Okamoto, and S. Ozawa of Fujifilm Corporation, Tokyo, Japan.
Publisher Copyright:
© 2020 American Society for Gastrointestinal Endoscopy
PY - 2020/10
Y1 - 2020/10
N2 - Background and aims: Oxygen saturation (OS) imaging is a novel technique that directly measures and visualizes the tissue oxygen saturation at the surface of the GI tract. Our purpose was to evaluate the ability of OS imaging to visualize the action mode of photodynamic therapy (PDT). Methods: Eight patients with local recurrence after chemoradiotherapy for esophageal cancer were enrolled. OS imaging observation was performed before PDT, after 100 J/cm2 illumination and illumination completion, and on the second day. Results: OS imaging showed an extreme change in the hypoxic state in the illuminated area, although the change was near invisible on white-light imaging. The median tissue oxygen saturation value at the tumor lesion was 61.5% (range, 36%-91%) before PDT and significantly decreased immediately after illumination: 11% (range, 0%-57%) after 100 J/cm2 illumination, 1% (range, 0%-6%) at PDT completion, and 2% (range, 0%-12%) on the second day. Conclusions: OS imaging could be a useful tool to visualize changes after PDT.
AB - Background and aims: Oxygen saturation (OS) imaging is a novel technique that directly measures and visualizes the tissue oxygen saturation at the surface of the GI tract. Our purpose was to evaluate the ability of OS imaging to visualize the action mode of photodynamic therapy (PDT). Methods: Eight patients with local recurrence after chemoradiotherapy for esophageal cancer were enrolled. OS imaging observation was performed before PDT, after 100 J/cm2 illumination and illumination completion, and on the second day. Results: OS imaging showed an extreme change in the hypoxic state in the illuminated area, although the change was near invisible on white-light imaging. The median tissue oxygen saturation value at the tumor lesion was 61.5% (range, 36%-91%) before PDT and significantly decreased immediately after illumination: 11% (range, 0%-57%) after 100 J/cm2 illumination, 1% (range, 0%-6%) at PDT completion, and 2% (range, 0%-12%) on the second day. Conclusions: OS imaging could be a useful tool to visualize changes after PDT.
UR - http://www.scopus.com/inward/record.url?scp=85089197525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089197525&partnerID=8YFLogxK
U2 - 10.1016/j.vgie.2020.07.003
DO - 10.1016/j.vgie.2020.07.003
M3 - Article
AN - SCOPUS:85089197525
SN - 2468-4481
VL - 5
SP - 496
EP - 499
JO - VideoGIE
JF - VideoGIE
IS - 10
ER -
