Purpose: To observe arterial oxygen in relation to fraction of inspired oxygen (F I O 2 ) during mechanical ventilation (MV). Materials and methods: In this multicenter prospective observational study, we included adult patients required MV for >48 h during the period from March to May 2015. We obtained F I O 2 , PaO 2 and SaO 2 from commencement of MV until the 7th day of MV in the ICU. Results: We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of F I O 2 , PaO 2 and SaO 2 were 0.40, 96 mm Hg and 98%. After day two, patients spent most of their time with a F I O 2 between 0.3 and 0.49 with median PaO 2 of approximately 90 mm Hg and SaO 2 of 97%. PaO 2 was ≥100 mm Hg during 47.2% of the study period and was ≥130 mm Hg during 18.4% of the study period. F I O 2 was more likely decreased when PaO 2 was ≥130 mm Hg or SaO 2 was ≥99% with a F I O 2 of 0.5 or greater. When F I O 2 was <0.5, however, F I O 2 was less likely decreased regardless of the value of PaO 2 and SaO 2 . Conclusions: In our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected.
- Arterial oxygen
- Fraction of inspired oxygen
- Mechanical ventilation
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine