OxLDL/β2GPI complexes and autoantibodies in patients with systemic lupus erythematosus, systemic sclerosis, and antiphospholipid syndrome: Pathogenic implications for vascular involvement

Luis R. Lopez, Daniel F. Simpson, Beth L. Hurley, Eiji Matsuura

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59 Citations (Scopus)

Abstract

Oxidized low-density lipoprotein (oxLDL) interacts with β2GPI, forming oxLDL/β2GPI complexes. Autoimmune vascular inflammation (and oxidative stress) may promote the formation of these complexes. The coexistence of oxLDL/β2GPI complexes with autoantibodies to these complexes suggests an active pro-atherogenic role in vascular thrombosis and atherosclerosis. Immunoglobulin G (IgG) anti-oxLDL/β2GPI antibodies have been regarded as pro-atherogenic, whereas IgM antibodies are thought to be anti-atherogenic. For this study, oxLDL/β2GPI complexes, IgG, and IgM anti-oxLDL/β2GPI antibodies were measured using enzyme-linked immunosorbent assay (ELISA). Measurements were taken in two patient groups: (1) those with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and rheumatoid arthritis (RA); and (2) those with primary and secondary antiphospholipid syndrome (APS). For oxLDL/β2GPI complexes, SLE and SSc patients had the highest mean optical densities (ODs) (P

Original languageEnglish
Pages (from-to)313-322
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1051
DOIs
Publication statusPublished - 2005

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Antiphospholipid Syndrome
Systemic Scleroderma
Systemic Lupus Erythematosus
Autoantibodies
Blood Vessels
Antibodies
Immunoglobulin G
Immunosorbents
Oxidative stress
Density (optical)
oxidized low density lipoprotein
Syndrome
Immunoglobulin M
Assays
Rheumatoid Arthritis
Atherosclerosis
Oxidative Stress
Thrombosis
Enzyme-Linked Immunosorbent Assay
Inflammation

Keywords

  • β2-glycoprotein I
  • Antiphospholipid syndrome
  • Atherosclerosis
  • Autoimmunity
  • Oxidized low-density lipoprotein
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Systemic sclerosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "OxLDL/β2GPI complexes and autoantibodies in patients with systemic lupus erythematosus, systemic sclerosis, and antiphospholipid syndrome: Pathogenic implications for vascular involvement",
abstract = "Oxidized low-density lipoprotein (oxLDL) interacts with β2GPI, forming oxLDL/β2GPI complexes. Autoimmune vascular inflammation (and oxidative stress) may promote the formation of these complexes. The coexistence of oxLDL/β2GPI complexes with autoantibodies to these complexes suggests an active pro-atherogenic role in vascular thrombosis and atherosclerosis. Immunoglobulin G (IgG) anti-oxLDL/β2GPI antibodies have been regarded as pro-atherogenic, whereas IgM antibodies are thought to be anti-atherogenic. For this study, oxLDL/β2GPI complexes, IgG, and IgM anti-oxLDL/β2GPI antibodies were measured using enzyme-linked immunosorbent assay (ELISA). Measurements were taken in two patient groups: (1) those with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and rheumatoid arthritis (RA); and (2) those with primary and secondary antiphospholipid syndrome (APS). For oxLDL/β2GPI complexes, SLE and SSc patients had the highest mean optical densities (ODs) (P",
keywords = "β2-glycoprotein I, Antiphospholipid syndrome, Atherosclerosis, Autoimmunity, Oxidized low-density lipoprotein, Rheumatoid arthritis, Systemic lupus erythematosus, Systemic sclerosis",
author = "Lopez, {Luis R.} and Simpson, {Daniel F.} and Hurley, {Beth L.} and Eiji Matsuura",
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T1 - OxLDL/β2GPI complexes and autoantibodies in patients with systemic lupus erythematosus, systemic sclerosis, and antiphospholipid syndrome

T2 - Pathogenic implications for vascular involvement

AU - Lopez, Luis R.

AU - Simpson, Daniel F.

AU - Hurley, Beth L.

AU - Matsuura, Eiji

PY - 2005

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KW - Systemic sclerosis

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