Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates

N. Bassi, S. Zampieri, A. Ghirardello, M. Tonon, M. Zen, S. Beggio, E. Matsuura, A. Doria

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

High levels of oxidized low-density liprotein/beta2 glycoprotein 1 (oxLDL/β2GPI) complexes and anti-complex IgG as well as IgM have been reported in SLE. We analysed this complex and Ab against the complex in SLE patients and evaluated their relationship with clinical and serological findings, traditional risk factors for atherosclerosis, and subclinical atherosclerosis. The prevalence and the levels of the complex and of anti-complex Ab were significantly higher in systemic lupus erythematosus (SLE) patients than in normal healthy donors (NHD). The titers of oxLDL/β2GPI were significantly higher in patients with renal involvement and previous thromboembolic episodes and were correlated with the number of risk factors for atherosclerosis, whereas they were significantly lower in patients with neurological involvement. Both IgG and IgM anti-complex Ab were associated with antiphospholipid (APL). In conclusion, the oxLDL/β2GPI complex as well as Ab against the complex are prevalent in SLE where they seem to be involved in organ damage.

Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalAutoimmunity
Volume42
Issue number4
DOIs
Publication statusPublished - Dec 3 2009

Keywords

  • AAb
  • Atherosclerosis
  • OxLDL
  • OxLDL/β2GPI complex
  • SLE
  • β2GPI

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates'. Together they form a unique fingerprint.

  • Cite this

    Bassi, N., Zampieri, S., Ghirardello, A., Tonon, M., Zen, M., Beggio, S., Matsuura, E., & Doria, A. (2009). Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates. Autoimmunity, 42(4), 289-291. https://doi.org/10.1080/08916930902828247