Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates

N. Bassi, S. Zampieri, A. Ghirardello, M. Tonon, M. Zen, S. Beggio, Eiji Matsuura, A. Doria

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

High levels of oxidized low-density liprotein/beta2 glycoprotein 1 (oxLDL/β2GPI) complexes and anti-complex IgG as well as IgM have been reported in SLE. We analysed this complex and Ab against the complex in SLE patients and evaluated their relationship with clinical and serological findings, traditional risk factors for atherosclerosis, and subclinical atherosclerosis. The prevalence and the levels of the complex and of anti-complex Ab were significantly higher in systemic lupus erythematosus (SLE) patients than in normal healthy donors (NHD). The titers of oxLDL/β2GPI were significantly higher in patients with renal involvement and previous thromboembolic episodes and were correlated with the number of risk factors for atherosclerosis, whereas they were significantly lower in patients with neurological involvement. Both IgG and IgM anti-complex Ab were associated with antiphospholipid (APL). In conclusion, the oxLDL/β2GPI complex as well as Ab against the complex are prevalent in SLE where they seem to be involved in organ damage.

Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalAutoimmunity
Volume42
Issue number4
DOIs
Publication statusPublished - 2009

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Systemic Lupus Erythematosus
Atherosclerosis
Glycoproteins
Tissue Donors
Kidney
anti-IgG
anti-IgM

Keywords

  • β2GPI
  • AAb
  • Atherosclerosis
  • OxLDL
  • OxLDL/β2GPI complex
  • SLE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bassi, N., Zampieri, S., Ghirardello, A., Tonon, M., Zen, M., Beggio, S., ... Doria, A. (2009). Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates. Autoimmunity, 42(4), 289-291. https://doi.org/10.1080/08916930902828247

Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle : Prevalence and Correlates. / Bassi, N.; Zampieri, S.; Ghirardello, A.; Tonon, M.; Zen, M.; Beggio, S.; Matsuura, Eiji; Doria, A.

In: Autoimmunity, Vol. 42, No. 4, 2009, p. 289-291.

Research output: Contribution to journalArticle

Bassi, N, Zampieri, S, Ghirardello, A, Tonon, M, Zen, M, Beggio, S, Matsuura, E & Doria, A 2009, 'Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates', Autoimmunity, vol. 42, no. 4, pp. 289-291. https://doi.org/10.1080/08916930902828247
Bassi N, Zampieri S, Ghirardello A, Tonon M, Zen M, Beggio S et al. Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle: Prevalence and Correlates. Autoimmunity. 2009;42(4):289-291. https://doi.org/10.1080/08916930902828247
Bassi, N. ; Zampieri, S. ; Ghirardello, A. ; Tonon, M. ; Zen, M. ; Beggio, S. ; Matsuura, Eiji ; Doria, A. / Oxldl/β2gpi Complex and Anti-oxldl/β2gpi in Sle : Prevalence and Correlates. In: Autoimmunity. 2009 ; Vol. 42, No. 4. pp. 289-291.
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