Oxidative stress in childhood meningitis: Measurement of 8-hydroxy-2'-deoxyguanosine concentration in cerebrospinal fluid

H. Tsukahara, T. Haruta, N. Ono, R. Kobata, Y. Fukumoto, M. Hiraoka, M. Mayumi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To examine the involvement of reactive oxygen species, we measured the concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative stress, in cerebrospinal fluid samples from 63 children with and without meningitis. We observed that the mean concentration of 8-OHdG in samples obtained during the early phase of bacterial meningitis, but not aseptic meningitis, was significantly higher than that in control samples. Clinical and laboratory improvement was associated with a fall in the 8-OHdG concentration in the patients with bacterial meningitis. Our findings suggest the presence of enhanced oxidative stress in the central nervous system of children with bacterial meningitis.

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalRedox Report
Volume5
Issue number5
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical

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