Oxidative stress biomarkers and lifestyles in Japanese healthy people

Noriko Sakano, Da Hong Wang, Noriko Takahashi, Bingling Wang, Rani Sauriasari, Sakiko Kanbara, Yoshie Sato, Tomoko Takigawa, Jiro Takaki, Keiki Ogino

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The urinary concentrations of 8-isoprostane and 8-hydroxy-2′-deoxyguanosine (8-OHdG), which are biomarkers of oxidative stress, were measured in 677 Japanese people without any diseases, and their correlations with lifestyle factors, lifestyle-related blood biochemical parameters, and dietary intake of antioxidative vitamins were investigated. The mean urinary concentration of 8-isoprostane and 8-OHdG was 0.58 ng/mg creatinine and 8.43 ng/mg creatinine, respectively. Mean urinary 8-isoprostane was significantly different in terms of age, gender, smoking and alcohol consumption but not different in terms of body mass index (BMI) and exercise. By multiple regression analysis, urinary 8-isoprostane was significantly influenced by smoking and age. On the other hand, mean urinary 8-OHdG showed differences only by age group. Multiple regression analysis revealed that urinary 8-OHdG was significantly influenced by age, smoking, body weight, levels of high-sensitivity C-reactive protein (Hs-CRP) and low density lipoprotein-cholesterol in females, although it was significantly influenced by body weight in males. The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP. Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level.

Original languageEnglish
Pages (from-to)185-195
Number of pages11
Journaljournal of clinical biochemistry and nutrition
Volume44
Issue number2
DOIs
Publication statusPublished - Mar 2009

Keywords

  • 8-OHdG
  • 8-isoprostane
  • Biomarkers
  • Cross-sectional study
  • Healthy people

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Oxidative stress biomarkers and lifestyles in Japanese healthy people'. Together they form a unique fingerprint.

  • Cite this

    Sakano, N., Wang, D. H., Takahashi, N., Wang, B., Sauriasari, R., Kanbara, S., Sato, Y., Takigawa, T., Takaki, J., & Ogino, K. (2009). Oxidative stress biomarkers and lifestyles in Japanese healthy people. journal of clinical biochemistry and nutrition, 44(2), 185-195. https://doi.org/10.3164/jcbn.08-252