Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet

Takaaki Tomofuji, Tetsuji Azuma, Hiroki Kusano, Toshihiro Sanbe, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Tatsuo Watanabe

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.

Original languageEnglish
Pages (from-to)3601-3604
Number of pages4
JournalFEBS Letters
Volume580
Issue number15
DOIs
Publication statusPublished - Jun 26 2006

Keywords

  • Dietary cholesterol
  • Periodontitis
  • Tissue oxidative damage

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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