Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet

Takaaki Tomofuji, Tetsuji Azuma, Hiroki Kusano, Toshihiro Sanbe, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Tatsuo Watanabe

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.

Original languageEnglish
Pages (from-to)3601-3604
Number of pages4
JournalFEBS Letters
Volume580
Issue number15
DOIs
Publication statusPublished - Jun 26 2006

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Dietary Cholesterol
Periodontitis
Nutrition
Rats
Cholesterol
Pathogens
Fibroblasts
Tissue
Diet
Cytokines
Lipopolysaccharides
Peptide Hydrolases
Health

Keywords

  • Dietary cholesterol
  • Periodontitis
  • Tissue oxidative damage

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Oxidative damage of periodontal tissue in the rat periodontitis model : Effects of a high-cholesterol diet. / Tomofuji, Takaaki; Azuma, Tetsuji; Kusano, Hiroki; Sanbe, Toshihiro; Ekuni, Daisuke; Tamaki, Naofumi; Yamamoto, Tatsuo; Watanabe, Tatsuo.

In: FEBS Letters, Vol. 580, No. 15, 26.06.2006, p. 3601-3604.

Research output: Contribution to journalArticle

Tomofuji, T, Azuma, T, Kusano, H, Sanbe, T, Ekuni, D, Tamaki, N, Yamamoto, T & Watanabe, T 2006, 'Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet', FEBS Letters, vol. 580, no. 15, pp. 3601-3604. https://doi.org/10.1016/j.febslet.2006.05.041
Tomofuji, Takaaki ; Azuma, Tetsuji ; Kusano, Hiroki ; Sanbe, Toshihiro ; Ekuni, Daisuke ; Tamaki, Naofumi ; Yamamoto, Tatsuo ; Watanabe, Tatsuo. / Oxidative damage of periodontal tissue in the rat periodontitis model : Effects of a high-cholesterol diet. In: FEBS Letters. 2006 ; Vol. 580, No. 15. pp. 3601-3604.
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