Oxidation of aromatic and aliphatic aldehydes to carboxylic acids by Geotrichum candidum aldehyde dehydrogenase

Tomoyasu Hoshino, Emi Yamabe, Muhammad Arisyi Hawari, Mayumi Tamura, Shuji Kanamaru, Keisuke Yoshida, Afifa Ayu Koesoema, Tomoko Matsuda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Oxidation reaction is one of the most important and indispensable organic reactions, so that green and sustainable catalysts for oxidation are necessary to be developed. Herein, biocatalytic oxidation of aldehydes was investigated, resulted in the synthesis of both aromatic and aliphatic carboxylic acids using a Geotrichum candidum aldehyde dehydrogenase (GcALDH). Moreover, selective oxidation of dialdehydes to aldehydic acids by GcALDH was also successful.

Original languageEnglish
Article number131387
JournalTetrahedron
Volume76
Issue number33
DOIs
Publication statusPublished - Aug 14 2020
Externally publishedYes

Keywords

  • Aldehyde
  • Aldehyde dehydrogenase
  • Carboxylic acid
  • Enzyme
  • Green chemistry
  • Oxidation
  • Selectivity

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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