Oxaliplatin-induced liver injury mimicking metastatic tumor on images

A case report

Kaori Uchino, Masayoshi Fujisawa, Takanori Watanabe, Yoshikatsu Endo, Tetsuji Nobuhisa, Yusuke Matsumoto, Kyohei Kai, Shiso Sato, Kenji Notohara, Akihiro Matsukawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Oxaliplatin-based chemotherapy is widely used for advanced colorectal cancer treatment, but it occasionally induces liver injury that is characterized histologically by sinusoidal dilatation, hepatic plate atrophy and/or venular obstruction. Most of the patients do not reveal apparent radiological abnormalities, however. Here, we report the case of a 47-year-old man with a radiologically detectable mass-forming oxaliplatin-induced sinusoidal injury that mimicked multiple liver tumors. These mass lesions were found on computed tomography images after the administration of six cycles of folinic acid, fluorouracil and oxaliplatin therapy as adjuvant chemotherapy for Stage III rectal cancer. The patient had to undergo liver resection because imaging studies could not exclude metastases. The histological examination revealed that a resected mass lesion was composed of severe sinusoidal dilatation. Milder dilatation was also seen in the surrounding parenchyma. We diagnosed the patient as having an oxaliplatininduced sinusoidal injury with severe deviation. As oxaliplatin is a standard agent in colorectal cancer therapy today, all clinicians and pathologists should be aware of such nonneoplastic lesions as one of the rare differential diagnoses of metastatic liver tumor, to prevent overtreatment.

Original languageEnglish
Article numberhyt113
Pages (from-to)1034-1038
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

oxaliplatin
Liver
Wounds and Injuries
Dilatation
Neoplasms
Colorectal Neoplasms
Leucovorin
Multiple Trauma
Adjuvant Chemotherapy
Rectal Neoplasms
Fluorouracil
Atrophy
Differential Diagnosis
Therapeutics
Tomography
Neoplasm Metastasis
Drug Therapy

Keywords

  • Colorectal liver metastases
  • Oxaliplatin
  • Sinusoidal obstruction syndrome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Oxaliplatin-induced liver injury mimicking metastatic tumor on images : A case report. / Uchino, Kaori; Fujisawa, Masayoshi; Watanabe, Takanori; Endo, Yoshikatsu; Nobuhisa, Tetsuji; Matsumoto, Yusuke; Kai, Kyohei; Sato, Shiso; Notohara, Kenji; Matsukawa, Akihiro.

In: Japanese Journal of Clinical Oncology, Vol. 43, No. 10, hyt113, 10.2013, p. 1034-1038.

Research output: Contribution to journalArticle

Uchino, K, Fujisawa, M, Watanabe, T, Endo, Y, Nobuhisa, T, Matsumoto, Y, Kai, K, Sato, S, Notohara, K & Matsukawa, A 2013, 'Oxaliplatin-induced liver injury mimicking metastatic tumor on images: A case report', Japanese Journal of Clinical Oncology, vol. 43, no. 10, hyt113, pp. 1034-1038. https://doi.org/10.1093/jjco/hyt113
Uchino, Kaori ; Fujisawa, Masayoshi ; Watanabe, Takanori ; Endo, Yoshikatsu ; Nobuhisa, Tetsuji ; Matsumoto, Yusuke ; Kai, Kyohei ; Sato, Shiso ; Notohara, Kenji ; Matsukawa, Akihiro. / Oxaliplatin-induced liver injury mimicking metastatic tumor on images : A case report. In: Japanese Journal of Clinical Oncology. 2013 ; Vol. 43, No. 10. pp. 1034-1038.
@article{0a2207164e0b4ec3a99bb960e73dc9b0,
title = "Oxaliplatin-induced liver injury mimicking metastatic tumor on images: A case report",
abstract = "Oxaliplatin-based chemotherapy is widely used for advanced colorectal cancer treatment, but it occasionally induces liver injury that is characterized histologically by sinusoidal dilatation, hepatic plate atrophy and/or venular obstruction. Most of the patients do not reveal apparent radiological abnormalities, however. Here, we report the case of a 47-year-old man with a radiologically detectable mass-forming oxaliplatin-induced sinusoidal injury that mimicked multiple liver tumors. These mass lesions were found on computed tomography images after the administration of six cycles of folinic acid, fluorouracil and oxaliplatin therapy as adjuvant chemotherapy for Stage III rectal cancer. The patient had to undergo liver resection because imaging studies could not exclude metastases. The histological examination revealed that a resected mass lesion was composed of severe sinusoidal dilatation. Milder dilatation was also seen in the surrounding parenchyma. We diagnosed the patient as having an oxaliplatininduced sinusoidal injury with severe deviation. As oxaliplatin is a standard agent in colorectal cancer therapy today, all clinicians and pathologists should be aware of such nonneoplastic lesions as one of the rare differential diagnoses of metastatic liver tumor, to prevent overtreatment.",
keywords = "Colorectal liver metastases, Oxaliplatin, Sinusoidal obstruction syndrome",
author = "Kaori Uchino and Masayoshi Fujisawa and Takanori Watanabe and Yoshikatsu Endo and Tetsuji Nobuhisa and Yusuke Matsumoto and Kyohei Kai and Shiso Sato and Kenji Notohara and Akihiro Matsukawa",
year = "2013",
month = "10",
doi = "10.1093/jjco/hyt113",
language = "English",
volume = "43",
pages = "1034--1038",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Oxaliplatin-induced liver injury mimicking metastatic tumor on images

T2 - A case report

AU - Uchino, Kaori

AU - Fujisawa, Masayoshi

AU - Watanabe, Takanori

AU - Endo, Yoshikatsu

AU - Nobuhisa, Tetsuji

AU - Matsumoto, Yusuke

AU - Kai, Kyohei

AU - Sato, Shiso

AU - Notohara, Kenji

AU - Matsukawa, Akihiro

PY - 2013/10

Y1 - 2013/10

N2 - Oxaliplatin-based chemotherapy is widely used for advanced colorectal cancer treatment, but it occasionally induces liver injury that is characterized histologically by sinusoidal dilatation, hepatic plate atrophy and/or venular obstruction. Most of the patients do not reveal apparent radiological abnormalities, however. Here, we report the case of a 47-year-old man with a radiologically detectable mass-forming oxaliplatin-induced sinusoidal injury that mimicked multiple liver tumors. These mass lesions were found on computed tomography images after the administration of six cycles of folinic acid, fluorouracil and oxaliplatin therapy as adjuvant chemotherapy for Stage III rectal cancer. The patient had to undergo liver resection because imaging studies could not exclude metastases. The histological examination revealed that a resected mass lesion was composed of severe sinusoidal dilatation. Milder dilatation was also seen in the surrounding parenchyma. We diagnosed the patient as having an oxaliplatininduced sinusoidal injury with severe deviation. As oxaliplatin is a standard agent in colorectal cancer therapy today, all clinicians and pathologists should be aware of such nonneoplastic lesions as one of the rare differential diagnoses of metastatic liver tumor, to prevent overtreatment.

AB - Oxaliplatin-based chemotherapy is widely used for advanced colorectal cancer treatment, but it occasionally induces liver injury that is characterized histologically by sinusoidal dilatation, hepatic plate atrophy and/or venular obstruction. Most of the patients do not reveal apparent radiological abnormalities, however. Here, we report the case of a 47-year-old man with a radiologically detectable mass-forming oxaliplatin-induced sinusoidal injury that mimicked multiple liver tumors. These mass lesions were found on computed tomography images after the administration of six cycles of folinic acid, fluorouracil and oxaliplatin therapy as adjuvant chemotherapy for Stage III rectal cancer. The patient had to undergo liver resection because imaging studies could not exclude metastases. The histological examination revealed that a resected mass lesion was composed of severe sinusoidal dilatation. Milder dilatation was also seen in the surrounding parenchyma. We diagnosed the patient as having an oxaliplatininduced sinusoidal injury with severe deviation. As oxaliplatin is a standard agent in colorectal cancer therapy today, all clinicians and pathologists should be aware of such nonneoplastic lesions as one of the rare differential diagnoses of metastatic liver tumor, to prevent overtreatment.

KW - Colorectal liver metastases

KW - Oxaliplatin

KW - Sinusoidal obstruction syndrome

UR - http://www.scopus.com/inward/record.url?scp=84885157534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885157534&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyt113

DO - 10.1093/jjco/hyt113

M3 - Article

VL - 43

SP - 1034

EP - 1038

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 10

M1 - hyt113

ER -