Abstract
An overexpression of inflammatory cytokines has been found in the lesional skin as well as peripheral blood in patients with psoriasis, although its etiological significance is not yet understood. In order to evaluate the cell type responsible for the elevated cytokines in the peripheral blood, we investigated cytokine profiles of the fractionated peripheral blood mononuclear cells (PBMCs) in 30 patients with psoriasis and 27 healthy controls. Without stimulation, higher levels of interleukin (IL)-1β, IL-6, and IL-8 were produced by freshly isolated PBMCs from the patients than those from the controls. In the fractionated PBMCs, the monocyte-rich fractions were mainly responsible for the production of these cytokines and mRNA. The elevated levels of monocyte-derived cytokine mRNAs decreased following successful treatment with cyclosporin A. Although no correlation was found between the cytokine levels and the psoriasis area and severity index (PASI) scores, patients with arthropathy showed significantly high production levels of IL-1β, IL-6, and IL-8. These findings suggest that monocytes are the major cell source producing inflammatory cytokines in the peripheral blood of psoriasis, and the increased cytokine levels are related to the coexistent arthropathy rather than the severity of cutaneous lesions. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 63-70 |
| Number of pages | 8 |
| Journal | Journal of Dermatological Science |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 1999 |
| Externally published | Yes |
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Keywords
- Cyclosporin A
- Cytokines
- Monocytes
- Psoriasis
ASJC Scopus subject areas
- Dermatology
Cite this
Overexpression of monocyte-derived cytokines in active psoriasis : A relation to coexistent arthropathy. / Nishibu, Akiko; Han, Gang Wen; Iwatsuki, Keiji; Matsui, Takashi; Inoue, Masayuki; Akiba, Hitoshi; Kaneko, Reiko; Kaneko, Fumio.
In: Journal of Dermatological Science, Vol. 21, No. 1, 09.1999, p. 63-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overexpression of monocyte-derived cytokines in active psoriasis
T2 - A relation to coexistent arthropathy
AU - Nishibu, Akiko
AU - Han, Gang Wen
AU - Iwatsuki, Keiji
AU - Matsui, Takashi
AU - Inoue, Masayuki
AU - Akiba, Hitoshi
AU - Kaneko, Reiko
AU - Kaneko, Fumio
PY - 1999/9
Y1 - 1999/9
N2 - An overexpression of inflammatory cytokines has been found in the lesional skin as well as peripheral blood in patients with psoriasis, although its etiological significance is not yet understood. In order to evaluate the cell type responsible for the elevated cytokines in the peripheral blood, we investigated cytokine profiles of the fractionated peripheral blood mononuclear cells (PBMCs) in 30 patients with psoriasis and 27 healthy controls. Without stimulation, higher levels of interleukin (IL)-1β, IL-6, and IL-8 were produced by freshly isolated PBMCs from the patients than those from the controls. In the fractionated PBMCs, the monocyte-rich fractions were mainly responsible for the production of these cytokines and mRNA. The elevated levels of monocyte-derived cytokine mRNAs decreased following successful treatment with cyclosporin A. Although no correlation was found between the cytokine levels and the psoriasis area and severity index (PASI) scores, patients with arthropathy showed significantly high production levels of IL-1β, IL-6, and IL-8. These findings suggest that monocytes are the major cell source producing inflammatory cytokines in the peripheral blood of psoriasis, and the increased cytokine levels are related to the coexistent arthropathy rather than the severity of cutaneous lesions. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - An overexpression of inflammatory cytokines has been found in the lesional skin as well as peripheral blood in patients with psoriasis, although its etiological significance is not yet understood. In order to evaluate the cell type responsible for the elevated cytokines in the peripheral blood, we investigated cytokine profiles of the fractionated peripheral blood mononuclear cells (PBMCs) in 30 patients with psoriasis and 27 healthy controls. Without stimulation, higher levels of interleukin (IL)-1β, IL-6, and IL-8 were produced by freshly isolated PBMCs from the patients than those from the controls. In the fractionated PBMCs, the monocyte-rich fractions were mainly responsible for the production of these cytokines and mRNA. The elevated levels of monocyte-derived cytokine mRNAs decreased following successful treatment with cyclosporin A. Although no correlation was found between the cytokine levels and the psoriasis area and severity index (PASI) scores, patients with arthropathy showed significantly high production levels of IL-1β, IL-6, and IL-8. These findings suggest that monocytes are the major cell source producing inflammatory cytokines in the peripheral blood of psoriasis, and the increased cytokine levels are related to the coexistent arthropathy rather than the severity of cutaneous lesions. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Cyclosporin A
KW - Cytokines
KW - Monocytes
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0032770052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032770052&partnerID=8YFLogxK
U2 - 10.1016/S0923-1811(99)00031-6
DO - 10.1016/S0923-1811(99)00031-6
M3 - Article
C2 - 10468194
AN - SCOPUS:0032770052
VL - 21
SP - 63
EP - 70
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 1
ER -