Overexpression of monocyte-derived cytokines in active psoriasis: A relation to coexistent arthropathy

Akiko Nishibu, Gang Wen Han, Keiji Iwatsuki, Takashi Matsui, Masayuki Inoue, Hitoshi Akiba, Reiko Kaneko, Fumio Kaneko

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21 Citations (Scopus)

Abstract

An overexpression of inflammatory cytokines has been found in the lesional skin as well as peripheral blood in patients with psoriasis, although its etiological significance is not yet understood. In order to evaluate the cell type responsible for the elevated cytokines in the peripheral blood, we investigated cytokine profiles of the fractionated peripheral blood mononuclear cells (PBMCs) in 30 patients with psoriasis and 27 healthy controls. Without stimulation, higher levels of interleukin (IL)-1β, IL-6, and IL-8 were produced by freshly isolated PBMCs from the patients than those from the controls. In the fractionated PBMCs, the monocyte-rich fractions were mainly responsible for the production of these cytokines and mRNA. The elevated levels of monocyte-derived cytokine mRNAs decreased following successful treatment with cyclosporin A. Although no correlation was found between the cytokine levels and the psoriasis area and severity index (PASI) scores, patients with arthropathy showed significantly high production levels of IL-1β, IL-6, and IL-8. These findings suggest that monocytes are the major cell source producing inflammatory cytokines in the peripheral blood of psoriasis, and the increased cytokine levels are related to the coexistent arthropathy rather than the severity of cutaneous lesions. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalJournal of dermatological science
Volume21
Issue number1
DOIs
Publication statusPublished - Sep 1 1999

Keywords

  • Cyclosporin A
  • Cytokines
  • Monocytes
  • Psoriasis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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    Nishibu, A., Han, G. W., Iwatsuki, K., Matsui, T., Inoue, M., Akiba, H., Kaneko, R., & Kaneko, F. (1999). Overexpression of monocyte-derived cytokines in active psoriasis: A relation to coexistent arthropathy. Journal of dermatological science, 21(1), 63-70. https://doi.org/10.1016/S0923-1811(99)00031-6