Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity

Ryo Tanaka; Toshiro Ono; Shuichiro Sato; Tetsuya Nakada; Fumihito Koizumi; Kosei Hasegawa; Kazuhiko Nakagawa; Hideo Okumura; Toshiharu Yamashita; Mikio Ohtsuka; Kenji Asagoe; Osamu Yamasaki; Yuji Noguchi; Keiji Iwatsuki; Eiichi Nakayama

doi:10.1111/j.1348-0421.2004.tb03515.x

Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity

Ryo Tanaka, Toshiro Ono, Shuichiro Sato, Tetsuya Nakada, Fumihito Koizumi, Kosei Hasegawa, Kazuhiko Nakagawa, Hideo Okumura, Toshiharu Yamashita, Mikio Ohtsuka, Kenji Asagoe, Osamu Yamasaki, Yuji Noguchi, Keiji Iwatsuki, Eiichi Nakayama

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.

Original language	English
Pages (from-to)	339-345
Number of pages	7
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	48
Issue number	4
DOIs	https://doi.org/10.1111/j.1348-0421.2004.tb03515.x
Publication status	Published - 2004

Keywords

Cancer
Over-expression
Real-time RT-PCR
TSGA10

ASJC Scopus subject areas

Microbiology
Immunology
Virology

Access to Document

10.1111/j.1348-0421.2004.tb03515.x

Fingerprint Dive into the research topics of 'Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity'. Together they form a unique fingerprint.

Cite this

Tanaka, R., Ono, T., Sato, S., Nakada, T., Koizumi, F., Hasegawa, K., Nakagawa, K., Okumura, H., Yamashita, T., Ohtsuka, M., Asagoe, K., Yamasaki, O., Noguchi, Y., Iwatsuki, K., & Nakayama, E. (2004). Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity. MICROBIOLOGY and IMMUNOLOGY, 48(4), 339-345. https://doi.org/10.1111/j.1348-0421.2004.tb03515.x

Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity. / Tanaka, Ryo; Ono, Toshiro; Sato, Shuichiro; Nakada, Tetsuya; Koizumi, Fumihito; Hasegawa, Kosei; Nakagawa, Kazuhiko; Okumura, Hideo; Yamashita, Toshiharu; Ohtsuka, Mikio; Asagoe, Kenji; Yamasaki, Osamu; Noguchi, Yuji; Iwatsuki, Keiji; Nakayama, Eiichi.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 48, No. 4, 2004, p. 339-345.

Research output: Contribution to journal › Article › peer-review

Tanaka, R, Ono, T, Sato, S, Nakada, T, Koizumi, F, Hasegawa, K, Nakagawa, K, Okumura, H, Yamashita, T, Ohtsuka, M, Asagoe, K, Yamasaki, O, Noguchi, Y, Iwatsuki, K & Nakayama, E 2004, 'Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity', MICROBIOLOGY and IMMUNOLOGY, vol. 48, no. 4, pp. 339-345. https://doi.org/10.1111/j.1348-0421.2004.tb03515.x

Tanaka, Ryo ; Ono, Toshiro ; Sato, Shuichiro ; Nakada, Tetsuya ; Koizumi, Fumihito ; Hasegawa, Kosei ; Nakagawa, Kazuhiko ; Okumura, Hideo ; Yamashita, Toshiharu ; Ohtsuka, Mikio ; Asagoe, Kenji ; Yamasaki, Osamu ; Noguchi, Yuji ; Iwatsuki, Keiji ; Nakayama, Eiichi. / Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity. In: MICROBIOLOGY and IMMUNOLOGY. 2004 ; Vol. 48, No. 4. pp. 339-345.

@article{3da58b6c13354306b6a52b1e7ae31a41,

title = "Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity",

abstract = "The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.",

keywords = "Cancer, Over-expression, Real-time RT-PCR, TSGA10",

author = "Ryo Tanaka and Toshiro Ono and Shuichiro Sato and Tetsuya Nakada and Fumihito Koizumi and Kosei Hasegawa and Kazuhiko Nakagawa and Hideo Okumura and Toshiharu Yamashita and Mikio Ohtsuka and Kenji Asagoe and Osamu Yamasaki and Yuji Noguchi and Keiji Iwatsuki and Eiichi Nakayama",

year = "2004",

doi = "10.1111/j.1348-0421.2004.tb03515.x",

language = "English",

volume = "48",

pages = "339--345",

journal = "Microbiology and Immunology",

issn = "0385-5600",

publisher = "Center for Academic Publications Japan",

number = "4",

}

TY - JOUR

T1 - Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity

AU - Tanaka, Ryo

AU - Ono, Toshiro

AU - Sato, Shuichiro

AU - Nakada, Tetsuya

AU - Koizumi, Fumihito

AU - Hasegawa, Kosei

AU - Nakagawa, Kazuhiko

AU - Okumura, Hideo

AU - Yamashita, Toshiharu

AU - Ohtsuka, Mikio

AU - Asagoe, Kenji

AU - Yamasaki, Osamu

AU - Noguchi, Yuji

AU - Iwatsuki, Keiji

AU - Nakayama, Eiichi

PY - 2004

Y1 - 2004

N2 - The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.

AB - The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.

KW - Cancer

KW - Over-expression

KW - Real-time RT-PCR

KW - TSGA10

UR - http://www.scopus.com/inward/record.url?scp=11144357926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144357926&partnerID=8YFLogxK

U2 - 10.1111/j.1348-0421.2004.tb03515.x

DO - 10.1111/j.1348-0421.2004.tb03515.x

M3 - Article

C2 - 15107545

AN - SCOPUS:11144357926

VL - 48

SP - 339

EP - 345

JO - Microbiology and Immunology

JF - Microbiology and Immunology

SN - 0385-5600

IS - 4

ER -

Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this