Abstract
The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.
Original language | English |
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Pages (from-to) | 339-345 |
Number of pages | 7 |
Journal | MICROBIOLOGY and IMMUNOLOGY |
Volume | 48 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2004 |
Keywords
- Cancer
- Over-expression
- Real-time RT-PCR
- TSGA10
ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology