TY - JOUR
T1 - Over-Expression of the Testis-Specific Gene TSGA10 in Cancers and Its Immunogenicity
AU - Tanaka, Ryo
AU - Ono, Toshiro
AU - Sato, Shuichiro
AU - Nakada, Tetsuya
AU - Koizumi, Fumihito
AU - Hasegawa, Kosei
AU - Nakagawa, Kazuhiko
AU - Okumura, Hideo
AU - Yamashita, Toshiharu
AU - Ohtsuka, Mikio
AU - Asagoe, Kenji
AU - Yamasaki, Osamu
AU - Noguchi, Yuji
AU - Iwatsuki, Keiji
AU - Nakayama, Eiichi
PY - 2004
Y1 - 2004
N2 - The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.
AB - The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.
KW - Cancer
KW - Over-expression
KW - Real-time RT-PCR
KW - TSGA10
UR - http://www.scopus.com/inward/record.url?scp=11144357926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144357926&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.2004.tb03515.x
DO - 10.1111/j.1348-0421.2004.tb03515.x
M3 - Article
C2 - 15107545
AN - SCOPUS:11144357926
VL - 48
SP - 339
EP - 345
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 4
ER -
