Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma

Keiko Fujii, Fumihiko Ishimaru, Koichi Nakase, Takayuki Tabayashi, Teruhiko Kozuka, Kyoko Naoki, Masayuki Miyahara, Hironobu Toki, Koichi Kitajima, Mine Harada, Mitsune Tanimoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.

Original languageEnglish
Pages (from-to)986-989
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number6
DOIs
Publication statusPublished - Mar 2003

Fingerprint

Adult T Cell Leukemia Lymphoma
Protein Isoforms
Ikaros Transcription Factor
Genes
Blast Crisis
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Southern Blotting
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disease Progression
B-Lymphocytes
Viruses
Infection

Keywords

  • Adult T-cell leukaemia/lymphoma
  • Aiolos
  • Helios
  • Ikaros
  • Short isoform

ASJC Scopus subject areas

  • Hematology

Cite this

Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma. / Fujii, Keiko; Ishimaru, Fumihiko; Nakase, Koichi; Tabayashi, Takayuki; Kozuka, Teruhiko; Naoki, Kyoko; Miyahara, Masayuki; Toki, Hironobu; Kitajima, Koichi; Harada, Mine; Tanimoto, Mitsune.

In: British Journal of Haematology, Vol. 120, No. 6, 03.2003, p. 986-989.

Research output: Contribution to journalArticle

Fujii, K, Ishimaru, F, Nakase, K, Tabayashi, T, Kozuka, T, Naoki, K, Miyahara, M, Toki, H, Kitajima, K, Harada, M & Tanimoto, M 2003, 'Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma', British Journal of Haematology, vol. 120, no. 6, pp. 986-989. https://doi.org/10.1046/j.1365-2141.2003.04216.x
Fujii, Keiko ; Ishimaru, Fumihiko ; Nakase, Koichi ; Tabayashi, Takayuki ; Kozuka, Teruhiko ; Naoki, Kyoko ; Miyahara, Masayuki ; Toki, Hironobu ; Kitajima, Koichi ; Harada, Mine ; Tanimoto, Mitsune. / Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma. In: British Journal of Haematology. 2003 ; Vol. 120, No. 6. pp. 986-989.
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