TY - JOUR
T1 - Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma
AU - Fujii, Keiko
AU - Ishimaru, Fumihiko
AU - Nakase, Koichi
AU - Tabayashi, Takayuki
AU - Kozuka, Teruhiko
AU - Naoki, Kyoko
AU - Miyahara, Masayuki
AU - Toki, Hironobu
AU - Kitajima, Koichi
AU - Harada, Mine
AU - Tanimoto, Mitsune
PY - 2003/3
Y1 - 2003/3
N2 - In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.
AB - In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.
KW - Adult T-cell leukaemia/lymphoma
KW - Aiolos
KW - Helios
KW - Ikaros
KW - Short isoform
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U2 - 10.1046/j.1365-2141.2003.04216.x
DO - 10.1046/j.1365-2141.2003.04216.x
M3 - Article
C2 - 12648068
AN - SCOPUS:0037353821
VL - 120
SP - 986
EP - 989
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 6
ER -
