Abstract
In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.
Original language | English |
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Pages (from-to) | 986-989 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 120 |
Issue number | 6 |
DOIs | |
Publication status | Published - Mar 2003 |
Keywords
- Adult T-cell leukaemia/lymphoma
- Aiolos
- Helios
- Ikaros
- Short isoform
ASJC Scopus subject areas
- Hematology