Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma

Keiko Fujii, Fumihiko Ishimaru, Koichi Nakase, Takayuki Tabayashi, Teruhiko Kozuka, Kyoko Naoki, Masayuki Miyahara, Hironobu Toki, Koichi Kitajima, Mine Harada, Mitsune Tanimoto

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

In previous studies, we demonstrated an over-expression of the dominant-negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B-cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over-expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T-cell ALL. In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma. In contrast, we could not detect any over-expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.

Original languageEnglish
Pages (from-to)986-989
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number6
DOIs
Publication statusPublished - Mar 2003

Keywords

  • Adult T-cell leukaemia/lymphoma
  • Aiolos
  • Helios
  • Ikaros
  • Short isoform

ASJC Scopus subject areas

  • Hematology

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