Ovarian bone morphogenetic proteins in female reproduction

Shunichi Shimasaki, R. Kelly Moore, Gregory F. Erickson, Fumio Otsuka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although bone morphogenetic proteins (BMPs) have been well-known regulators in ectopic formation of bone and cartilage, as well as in early embryonic development, nothing was known about the role of the BMP system in regulating ovarian function until recently. We demonstrated for the first time that the BMP system exists in the mammalian ovary and plays key roles in regulating important granulosa cell (GC) functions. Specifically, all BMPs we examined, including BMP-4, -6, -7, and -15, inhibit follicle-stimulating hormone (FSH)-dependent progesterone synthesis by primary cultures of rat granulosa cells. Thus, our observations provided experimental support for the hypothesis that BMPs may be a physiologically relevant luteinization inhibitor in growing ovarian follicles. BMP-7 and -15, but not BMP-6, are mitogens for granulosa cells. BMP-6 and BMP-15 are potent inhibitors of FSH action, by suppressing adenylate cyclase activity and FSH receptor expression, respectively. BMP-15 stimulates kit ligand (KL) expression, whereas kit ligand inhibits BMP-15 expression, thus forming a novel oocyte-somatic cell negative feedback loop. The physiological importance of the BMP system for normal mammalian reproduction has been established by the elucidation of the aberrant reproductive phenotypes of animals having mutated genes encoding BMP family members. Here we provide the recent advances in our understanding of the functions of BMPs in the ovary.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalInternational Congress Series
Volume1266
Issue numberC
DOIs
Publication statusPublished - Apr 1 2004
Externally publishedYes

Fingerprint

Bone Morphogenetic Proteins
Reproduction
Bone Morphogenetic Protein 15
Bone Morphogenetic Protein 6
Granulosa Cells
Stem Cell Factor
Follicle Stimulating Hormone
Ovary
Bone Morphogenetic Protein 4
Luteinization
Bone Morphogenetic Protein 7
FSH Receptors
Ovarian Follicle
Mitogens
Adenylyl Cyclases
Osteogenesis
Cartilage
Oocytes
Embryonic Development
Progesterone

Keywords

  • Bone morphogenetic protein
  • Fertility, ovary
  • Granulosa cell
  • Oocyte
  • Ovulation
  • Reproduction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ovarian bone morphogenetic proteins in female reproduction. / Shimasaki, Shunichi; Moore, R. Kelly; Erickson, Gregory F.; Otsuka, Fumio.

In: International Congress Series, Vol. 1266, No. C, 01.04.2004, p. 241-247.

Research output: Contribution to journalArticle

Shimasaki, Shunichi ; Moore, R. Kelly ; Erickson, Gregory F. ; Otsuka, Fumio. / Ovarian bone morphogenetic proteins in female reproduction. In: International Congress Series. 2004 ; Vol. 1266, No. C. pp. 241-247.
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