Outcomes of primary nephrotic syndrome in elderly Japanese

retrospective analysis of the Japan Renal Biopsy Registry (J-RBR)

Hitoshi Yokoyama, Hitoshi Sugiyama, Ichiei Narita, Takao Saito, Kunihiro Yamagata, Saori Nishio, Shouichi Fujimoto, Noriko Mori, Yukio Yuzawa, Seiya Okuda, Shoichi Maruyama, Hiroshi Sato, Yoshihiko Ueda, Hirofumi Makino, Seiichi Matsuo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and objectives: There are very little data available regarding nephrotic syndrome (NS) in elderly (aged ≥65 years) Japanese. The aim of this study was to examine the causes and outcomes of NS in elderly patients who underwent renal biopsies between 2007 and 2010. Design, setting, participants, and measurements: From July 2007 to June 2010, all of the elderly (aged ≥65 years) Japanese primary NS patients who underwent native renal biopsies and were registered in the Japan renal biopsy registry (J-RBR; 438 patients including 226 males and 212 females) were identified. From this cohort, 61 patients [28 males and 33 females including 29, 19, 6, 4, and 3 patients with membranous nephropathy (MN), minimal change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN), and other conditions, respectively] were registered from the representative multi-centers over all districts of Japan, and analyzed retrospectively. The treatment outcome was assessed using proteinuria-based criteria; i.e., complete remission (CR) was defined as urinary protein level of

Original languageEnglish
Pages (from-to)496-505
Number of pages10
JournalClinical and Experimental Nephrology
Volume19
Issue number3
DOIs
Publication statusPublished - Jun 17 2015

Fingerprint

Nephrotic Syndrome
Registries
Japan
Kidney
Biopsy
Membranoproliferative Glomerulonephritis
Lipoid Nephrosis
Focal Segmental Glomerulosclerosis
Membranous Glomerulonephritis
Proteinuria
Proteins

Keywords

  • Complication
  • Elderly
  • Immunosuppressive therapy
  • Japanese
  • Nephrotic syndrome
  • Outcome

ASJC Scopus subject areas

  • Nephrology
  • Physiology
  • Physiology (medical)

Cite this

Outcomes of primary nephrotic syndrome in elderly Japanese : retrospective analysis of the Japan Renal Biopsy Registry (J-RBR). / Yokoyama, Hitoshi; Sugiyama, Hitoshi; Narita, Ichiei; Saito, Takao; Yamagata, Kunihiro; Nishio, Saori; Fujimoto, Shouichi; Mori, Noriko; Yuzawa, Yukio; Okuda, Seiya; Maruyama, Shoichi; Sato, Hiroshi; Ueda, Yoshihiko; Makino, Hirofumi; Matsuo, Seiichi.

In: Clinical and Experimental Nephrology, Vol. 19, No. 3, 17.06.2015, p. 496-505.

Research output: Contribution to journalArticle

Yokoyama, H, Sugiyama, H, Narita, I, Saito, T, Yamagata, K, Nishio, S, Fujimoto, S, Mori, N, Yuzawa, Y, Okuda, S, Maruyama, S, Sato, H, Ueda, Y, Makino, H & Matsuo, S 2015, 'Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR)', Clinical and Experimental Nephrology, vol. 19, no. 3, pp. 496-505. https://doi.org/10.1007/s10157-014-1022-x
Yokoyama, Hitoshi ; Sugiyama, Hitoshi ; Narita, Ichiei ; Saito, Takao ; Yamagata, Kunihiro ; Nishio, Saori ; Fujimoto, Shouichi ; Mori, Noriko ; Yuzawa, Yukio ; Okuda, Seiya ; Maruyama, Shoichi ; Sato, Hiroshi ; Ueda, Yoshihiko ; Makino, Hirofumi ; Matsuo, Seiichi. / Outcomes of primary nephrotic syndrome in elderly Japanese : retrospective analysis of the Japan Renal Biopsy Registry (J-RBR). In: Clinical and Experimental Nephrology. 2015 ; Vol. 19, No. 3. pp. 496-505.
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