TY - JOUR
T1 - Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma
AU - Ohnishi, Hideki
AU - Sakaguchi, Kohsaku
AU - Nouso, Kazuhiro
AU - Kobayashi, Yoshiyuki
AU - Nakamura, Shinichiro
AU - Tanaka, Hironori
AU - Miyake, Yasuhiro
AU - Shoji, Bon
AU - Iwadou, Shouta
AU - Shiratori, Yasushi
PY - 2010/9
Y1 - 2010/9
N2 - Purpose: Hepatic lesions identified by computed tomography (CT) during arterial portography (CTAP) or CT hepatic arteriography (CTHA) in hepatocellular carcinoma (HCC) patients are sometimes too small to be diagnosed as HCC. We undertook this cohort study to assess whether these small lesions are actually HCC, and to clarify the effectiveness of these imaging examinations in a clinical setting. Methods: We assessed the characteristics of 74 tiny lesions detected by CTAP and/or CTHA, but not by CT in 67 patients. Results: Seven out of 10 nodules were histologically confirmed as HCC and 18 out of 64 lesions increased in size and showed typical findings of HCC during the follow-up period. Multivariate analysis revealed that the size of the main tumor (>30 mm in diameter) was associated with the presence of tiny additional HCC lesions (P = 0.002). Conclusions: These findings indicate that CTAP and CTHA are recommended for determining the stage of HCC, especially when the HCC nodule is larger than 30 mm in diameter.
AB - Purpose: Hepatic lesions identified by computed tomography (CT) during arterial portography (CTAP) or CT hepatic arteriography (CTHA) in hepatocellular carcinoma (HCC) patients are sometimes too small to be diagnosed as HCC. We undertook this cohort study to assess whether these small lesions are actually HCC, and to clarify the effectiveness of these imaging examinations in a clinical setting. Methods: We assessed the characteristics of 74 tiny lesions detected by CTAP and/or CTHA, but not by CT in 67 patients. Results: Seven out of 10 nodules were histologically confirmed as HCC and 18 out of 64 lesions increased in size and showed typical findings of HCC during the follow-up period. Multivariate analysis revealed that the size of the main tumor (>30 mm in diameter) was associated with the presence of tiny additional HCC lesions (P = 0.002). Conclusions: These findings indicate that CTAP and CTHA are recommended for determining the stage of HCC, especially when the HCC nodule is larger than 30 mm in diameter.
KW - CT during arterial portography
KW - CT hepatic arteriography
KW - Diagnosis
KW - Hepatocellular carcinoma
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U2 - 10.1007/s12072-010-9190-6
DO - 10.1007/s12072-010-9190-6
M3 - Article
C2 - 21063478
AN - SCOPUS:77958096628
VL - 4
SP - 562
EP - 568
JO - Hepatology International
JF - Hepatology International
SN - 1936-0533
IS - 3
ER -