Outcome of patients with inconsistent results from 13C-urea breath test and bacterial culture at the time of assessment of Helicobacter pylori eradication therapy in Japan

Yasuhiro Nagahara, Motowo Mizuno, Toshirou Maga, Kuniharu Ishiki, Tetsuji Okuno, Tomowo Yoshida, Kenji Yokota, Keiji Oguma, Hiroyuki Okada, Takao Tsuji

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Aims: At the assessment of eradication therapy of Helicobacter pylori, the results of 13C-urea breath test and other methods such as bacterial culture are occasionally inconsistent. In this study, we examined the outcomes of inconsistent results. Methodology: Four hundred and four patients with peptic ulcer who were H. pylori-positive and who had completed eradication therapy were studied. Bacterial culture, rapid urease tests and 13C-urea breath test were performed between one and three months after the end of the therapy. The cut-off value for the 13C-urea breath test used originally in this study was 2.5 per mil. We investigated the outcome of inconsistent results by following up the patients every 6 to 12 months. Results: At the initial assessment of eradication therapy, we observed inconsistent results with bacterial culture and 13C-urea breath test in 43 of 404 patients. Most of them (40 of 43) were culture-negative but urea breath test-positive, and the majority became negative for both tests. Based on the follow-up results, the optimum value for 13C-urea breath test at the assessment of eradication therapy was found to be 3.5 per mil. Conclusions: We found that outcomes of inconsistent results were variable, indicating the importance of the follow-up of patients after eradication therapy of H. pylori.

Original languageEnglish
Pages (from-to)1700-1703
Number of pages4
JournalHepato-Gastroenterology
Volume50
Issue number53
Publication statusPublished - Sep 2003

Fingerprint

Breath Tests
Helicobacter pylori
Urea
Japan
Therapeutics
Urease
Peptic Ulcer

Keywords

  • C-urea breath test
  • Cut-off value
  • Eradication therapy
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Outcome of patients with inconsistent results from 13C-urea breath test and bacterial culture at the time of assessment of Helicobacter pylori eradication therapy in Japan. / Nagahara, Yasuhiro; Mizuno, Motowo; Maga, Toshirou; Ishiki, Kuniharu; Okuno, Tetsuji; Yoshida, Tomowo; Yokota, Kenji; Oguma, Keiji; Okada, Hiroyuki; Tsuji, Takao.

In: Hepato-Gastroenterology, Vol. 50, No. 53, 09.2003, p. 1700-1703.

Research output: Contribution to journalArticle

Nagahara, Yasuhiro ; Mizuno, Motowo ; Maga, Toshirou ; Ishiki, Kuniharu ; Okuno, Tetsuji ; Yoshida, Tomowo ; Yokota, Kenji ; Oguma, Keiji ; Okada, Hiroyuki ; Tsuji, Takao. / Outcome of patients with inconsistent results from 13C-urea breath test and bacterial culture at the time of assessment of Helicobacter pylori eradication therapy in Japan. In: Hepato-Gastroenterology. 2003 ; Vol. 50, No. 53. pp. 1700-1703.
@article{3adb86850d754090815d21235b02a067,
title = "Outcome of patients with inconsistent results from 13C-urea breath test and bacterial culture at the time of assessment of Helicobacter pylori eradication therapy in Japan",
abstract = "Background/Aims: At the assessment of eradication therapy of Helicobacter pylori, the results of 13C-urea breath test and other methods such as bacterial culture are occasionally inconsistent. In this study, we examined the outcomes of inconsistent results. Methodology: Four hundred and four patients with peptic ulcer who were H. pylori-positive and who had completed eradication therapy were studied. Bacterial culture, rapid urease tests and 13C-urea breath test were performed between one and three months after the end of the therapy. The cut-off value for the 13C-urea breath test used originally in this study was 2.5 per mil. We investigated the outcome of inconsistent results by following up the patients every 6 to 12 months. Results: At the initial assessment of eradication therapy, we observed inconsistent results with bacterial culture and 13C-urea breath test in 43 of 404 patients. Most of them (40 of 43) were culture-negative but urea breath test-positive, and the majority became negative for both tests. Based on the follow-up results, the optimum value for 13C-urea breath test at the assessment of eradication therapy was found to be 3.5 per mil. Conclusions: We found that outcomes of inconsistent results were variable, indicating the importance of the follow-up of patients after eradication therapy of H. pylori.",
keywords = "C-urea breath test, Cut-off value, Eradication therapy, Helicobacter pylori",
author = "Yasuhiro Nagahara and Motowo Mizuno and Toshirou Maga and Kuniharu Ishiki and Tetsuji Okuno and Tomowo Yoshida and Kenji Yokota and Keiji Oguma and Hiroyuki Okada and Takao Tsuji",
year = "2003",
month = "9",
language = "English",
volume = "50",
pages = "1700--1703",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "53",

}

TY - JOUR

T1 - Outcome of patients with inconsistent results from 13C-urea breath test and bacterial culture at the time of assessment of Helicobacter pylori eradication therapy in Japan

AU - Nagahara, Yasuhiro

AU - Mizuno, Motowo

AU - Maga, Toshirou

AU - Ishiki, Kuniharu

AU - Okuno, Tetsuji

AU - Yoshida, Tomowo

AU - Yokota, Kenji

AU - Oguma, Keiji

AU - Okada, Hiroyuki

AU - Tsuji, Takao

PY - 2003/9

Y1 - 2003/9

N2 - Background/Aims: At the assessment of eradication therapy of Helicobacter pylori, the results of 13C-urea breath test and other methods such as bacterial culture are occasionally inconsistent. In this study, we examined the outcomes of inconsistent results. Methodology: Four hundred and four patients with peptic ulcer who were H. pylori-positive and who had completed eradication therapy were studied. Bacterial culture, rapid urease tests and 13C-urea breath test were performed between one and three months after the end of the therapy. The cut-off value for the 13C-urea breath test used originally in this study was 2.5 per mil. We investigated the outcome of inconsistent results by following up the patients every 6 to 12 months. Results: At the initial assessment of eradication therapy, we observed inconsistent results with bacterial culture and 13C-urea breath test in 43 of 404 patients. Most of them (40 of 43) were culture-negative but urea breath test-positive, and the majority became negative for both tests. Based on the follow-up results, the optimum value for 13C-urea breath test at the assessment of eradication therapy was found to be 3.5 per mil. Conclusions: We found that outcomes of inconsistent results were variable, indicating the importance of the follow-up of patients after eradication therapy of H. pylori.

AB - Background/Aims: At the assessment of eradication therapy of Helicobacter pylori, the results of 13C-urea breath test and other methods such as bacterial culture are occasionally inconsistent. In this study, we examined the outcomes of inconsistent results. Methodology: Four hundred and four patients with peptic ulcer who were H. pylori-positive and who had completed eradication therapy were studied. Bacterial culture, rapid urease tests and 13C-urea breath test were performed between one and three months after the end of the therapy. The cut-off value for the 13C-urea breath test used originally in this study was 2.5 per mil. We investigated the outcome of inconsistent results by following up the patients every 6 to 12 months. Results: At the initial assessment of eradication therapy, we observed inconsistent results with bacterial culture and 13C-urea breath test in 43 of 404 patients. Most of them (40 of 43) were culture-negative but urea breath test-positive, and the majority became negative for both tests. Based on the follow-up results, the optimum value for 13C-urea breath test at the assessment of eradication therapy was found to be 3.5 per mil. Conclusions: We found that outcomes of inconsistent results were variable, indicating the importance of the follow-up of patients after eradication therapy of H. pylori.

KW - C-urea breath test

KW - Cut-off value

KW - Eradication therapy

KW - Helicobacter pylori

UR - http://www.scopus.com/inward/record.url?scp=10744223337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744223337&partnerID=8YFLogxK

M3 - Article

C2 - 14571821

AN - SCOPUS:10744223337

VL - 50

SP - 1700

EP - 1703

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 53

ER -