Outcome of living-donor lobar lung transplantation using a single donor

Hiroshi Date, Takeshi Shiraishi, Seiichiro Sugimoto, Tsuyoshi Shoji, Fengshi Chen, Masafumi Hiratsuka, Akihiro Aoyama, Masaaki Sato, Masaomi Yamane, Akinori Iwasaki, Shinichiro Miyoshi, Toru Bando, Takahiro Oto

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Living-donor lobar lung transplantation usually requires 2 healthy donors who donate either a right or a left lower lobe; however, finding 2 healthy donors is difficult. Several case reports have been published on successful living-donor lobar lung transplantation using a single donor; however, little is known about its outcome. Methods: We retrospectively investigated 14 critically ill patients who had undergone single living-donor lobar lung transplantation at 3 lung transplant centers in Japan. There were 10 female and 4 male patients, including 10 children and 4 adults. Size matching was assessed by estimated graft forced vital capacity and 3-dimensional computed tomography volumetry. The diagnoses included complications of allogeneic hematopoietic stem cell transplantation (n = 6), pulmonary hypertension (n = 4), and others (n = 4). Results: At a mean follow-up of 45 months (range, 2-128), the 3- and 5-year survival rate was 70% and 56%, respectively. There were 4 early deaths, for a hospital mortality of 29%, with 1 additional death at 40 months. The main cause of early death was primary graft dysfunction, most likely related to size mismatching. The survival among these 14 patients was significantly worse than the survival in a group of 78 patients undergoing bilateral living-donor lobar lung transplantation during the same period (P = .044). Conclusions: Single living-donor lobar lung transplantation provides acceptable results for sick patients who would die soon otherwise. However, bilateral living-donor lobar lung transplantation appears to be a better option if 2 living donors are found.

Original languageEnglish
Pages (from-to)710-715
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume144
Issue number3
DOIs
Publication statusPublished - Sep 2012

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Lung Transplantation
Living Donors
Tissue Donors
Primary Graft Dysfunction
Transplants
Survival
Hematopoietic Stem Cell Transplantation
Vital Capacity
Hospital Mortality
Pulmonary Hypertension
Critical Illness
Cause of Death
Japan
Survival Rate
Tomography
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Outcome of living-donor lobar lung transplantation using a single donor. / Date, Hiroshi; Shiraishi, Takeshi; Sugimoto, Seiichiro; Shoji, Tsuyoshi; Chen, Fengshi; Hiratsuka, Masafumi; Aoyama, Akihiro; Sato, Masaaki; Yamane, Masaomi; Iwasaki, Akinori; Miyoshi, Shinichiro; Bando, Toru; Oto, Takahiro.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 144, No. 3, 09.2012, p. 710-715.

Research output: Contribution to journalArticle

Date, H, Shiraishi, T, Sugimoto, S, Shoji, T, Chen, F, Hiratsuka, M, Aoyama, A, Sato, M, Yamane, M, Iwasaki, A, Miyoshi, S, Bando, T & Oto, T 2012, 'Outcome of living-donor lobar lung transplantation using a single donor', Journal of Thoracic and Cardiovascular Surgery, vol. 144, no. 3, pp. 710-715. https://doi.org/10.1016/j.jtcvs.2012.05.054
Date, Hiroshi ; Shiraishi, Takeshi ; Sugimoto, Seiichiro ; Shoji, Tsuyoshi ; Chen, Fengshi ; Hiratsuka, Masafumi ; Aoyama, Akihiro ; Sato, Masaaki ; Yamane, Masaomi ; Iwasaki, Akinori ; Miyoshi, Shinichiro ; Bando, Toru ; Oto, Takahiro. / Outcome of living-donor lobar lung transplantation using a single donor. In: Journal of Thoracic and Cardiovascular Surgery. 2012 ; Vol. 144, No. 3. pp. 710-715.
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AU - Chen, Fengshi

AU - Hiratsuka, Masafumi

AU - Aoyama, Akihiro

AU - Sato, Masaaki

AU - Yamane, Masaomi

AU - Iwasaki, Akinori

AU - Miyoshi, Shinichiro

AU - Bando, Toru

AU - Oto, Takahiro

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