Abstract
Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.
| Original language | English |
|---|---|
| Title of host publication | Skin Cancer - A World-Wide Perspective |
| Publisher | Springer Berlin Heidelberg |
| Pages | 355-369 |
| Number of pages | 15 |
| ISBN (Print) | 9783642050718 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Medicine(all)
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Other therapies. / Iwatsuki, Keiji; Hatta, Naohito; Elwan, Nagwa M.; Ugurel, Selma; Lockwood, Lauren L.; Becker, Jürgen C.
Skin Cancer - A World-Wide Perspective. Springer Berlin Heidelberg, 2011. p. 355-369.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Other therapies
AU - Iwatsuki, Keiji
AU - Hatta, Naohito
AU - Elwan, Nagwa M.
AU - Ugurel, Selma
AU - Lockwood, Lauren L.
AU - Becker, Jürgen C.
PY - 2011
Y1 - 2011
N2 - Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.
AB - Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.
UR - http://www.scopus.com/inward/record.url?scp=84891472143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891472143&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-05072-5_25
DO - 10.1007/978-3-642-05072-5_25
M3 - Chapter
AN - SCOPUS:84891472143
SN - 9783642050718
SP - 355
EP - 369
BT - Skin Cancer - A World-Wide Perspective
PB - Springer Berlin Heidelberg
ER -