Other therapies

Keiji Iwatsuki; Naohito Hatta; Nagwa M. Elwan; Selma Ugurel; Lauren L. Lockwood; Jürgen C. Becker

doi:10.1007/978-3-642-05072-5_25

Other therapies

Keiji Iwatsuki, Naohito Hatta, Nagwa M. Elwan, Selma Ugurel, Lauren L. Lockwood, Jürgen C. Becker

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.

Original language	English
Title of host publication	Skin Cancer - A World-Wide Perspective
Publisher	Springer Berlin Heidelberg
Pages	355-369
Number of pages	15
ISBN (Print)	9783642050718
DOIs	https://doi.org/10.1007/978-3-642-05072-5_25
Publication status	Published - 2011

ASJC Scopus subject areas

Medicine(all)

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title = "Other therapies",

abstract = "Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.",

author = "Keiji Iwatsuki and Naohito Hatta and Elwan, {Nagwa M.} and Selma Ugurel and Lockwood, {Lauren L.} and Becker, {J{\"u}rgen C.}",

year = "2011",

doi = "10.1007/978-3-642-05072-5_25",

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T1 - Other therapies

AU - Iwatsuki, Keiji

AU - Hatta, Naohito

AU - Elwan, Nagwa M.

AU - Ugurel, Selma

AU - Lockwood, Lauren L.

AU - Becker, Jürgen C.

PY - 2011

Y1 - 2011

N2 - Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.

AB - Prognostic factors for Langerhans cell histiocytosis (LCH) or class I histiocytosis may include: (1) the number of organs involved, (2) the severity of organ failure, and (3) the age of the patients. Complications such as hemophagocytic syndrome and thrombocytopenia also affect the prognosis [1-4]. In general, younger patients with widely disseminated disease and organ dysfunction have a high risk of mortality. In a series of 101 children with LCH [2], the overall survival rate was 79% at 1 year, 74% at 3 years, and 71% at 5 years; however, in patients with liver or spleen involvement, 1-year survival was 33% and 5-year survival was only 25%. In adult LCH [3], the probability of survival 5 years post diagnosis was 92.3% overall: 100% for patients with single-system disease, 87.8% for isolated pulmonary disease, and 91.7% for multisystem disease.

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