Osteosarcoma of the pelvis: Experience of the Cooperative Osteosarcoma Study Group

Toshifumi Ozaki, Silke Flege, Matthias Kevric, Norbert Lindner, Rainer Maas, Günter Delling, Rudolf Schwarz, Arthur R. Von Hochstetter, Mechthild Salzer-Kuntschik, Wolfgang E. Berdel, Heribert Jürgens, G. Ulrich Exner, Peter Reichardt, Regine Mayer-Steinacker, Volker Ewerbeck, Rainer Kotz, Winfried Winkelmann, Stefan S. Bielack

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Abstract

Purpose: To define patients and tumor characteristics as well as therapy results, patients with pelvic osteosarcoma who were registered in the Cooperative Osteosarcoma Study Group (COSS) were analyzed. Patients and Methods: Sixty-seven patients with a high-grade pelvic osteosarcoma were eligible for this analysis. Fifteen patients had primary metastases. All patients received chemotherapy according to COSS protocols. Thirty-eight patients underwent limb-sparing surgery, 12 patients underwent hemipelvectomy, and 17 patients did not undergo definitive surgery. Eleven patients received irradiation to the primary tumor site: four postoperatively and seven as the only form of local therapy. Results: Local failure occurred in 47 of all 67 patients (70%) and in 31 of 50 patients (62%) who underwent definitive surgery. Five-year overall survival (OS) and progression-free survival rates were 27% and 19%, respectively. Large tumor size (P = .0137), primary metastases (P = .0001), and no or intralesional surgery (P < .0001) were poor prognostic factors. In 30 patients with no or intralesional surgery, 11 patients with radiotherapy had better OS than 19 patients without radiotherapy (P = .0033). Among the variables, primary metastasis, large tumor, no or intralesional surgery, no radiotherapy, existence of primary metastasis (relative risk [RR] = 3.456; P = .0009), surgical margin (intralesional or no surgical excision; RR = 5.619; P < .0001), and no radiotherapy (RR = 4.196; P = .0059) were independent poor prognostic factors. Conclusion: An operative approach with wide or marginal margins improves local control and OS. If the surgical margin is intralesional or excision is impossible, additional radiotherapy has a positive influence on prognosis.

Original languageEnglish
Pages (from-to)334-341
Number of pages8
JournalJournal of Clinical Oncology
Volume21
Issue number2
DOIs
Publication statusPublished - Jan 15 2003

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ozaki, T., Flege, S., Kevric, M., Lindner, N., Maas, R., Delling, G., Schwarz, R., Von Hochstetter, A. R., Salzer-Kuntschik, M., Berdel, W. E., Jürgens, H., Exner, G. U., Reichardt, P., Mayer-Steinacker, R., Ewerbeck, V., Kotz, R., Winkelmann, W., & Bielack, S. S. (2003). Osteosarcoma of the pelvis: Experience of the Cooperative Osteosarcoma Study Group. Journal of Clinical Oncology, 21(2), 334-341. https://doi.org/10.1200/JCO.2003.01.142