TY - JOUR
T1 - Osteocalcin-immunoreactive neurons in the vagal and glossopharyngeal sensory ganglia of the rat
AU - Ichikawa, H.
AU - Jin, H. W.
AU - Fujita, M.
AU - Nagaoka, N.
AU - Sugimoto, Tomosada
N1 - Funding Information:
This work was supported by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology to H.I. (No. 14571733).
PY - 2005/1/7
Y1 - 2005/1/7
N2 - Immunohistochemistry for osteocalcin (OC) was performed on the rat vagal and glossopharyngeal sensory ganglia. OC-immunoreactive (IR) neurons were detected in the jugular (10%), petrosal (11%) and nodose ganglia (6%). The cell size analysis demonstrated that OC-IR neurons were predominantly small to medium-sized in the jugular ganglion (mean±S.D.=356.3±192.2 μm 2, range=86.5-831.5 μm 2). On the other hand, such neurons were medium-sized to large in the petrosal (mean±S.D.=725. 6±280.7 μm 2, range=124.7-1540.4 μm 2) and nodose ganglia (mean±S.D.=857.5±330.2 μm 2, range=367.1-1608.0 μm 2). In the circumvallate papilla, OC-IR nerve fibers were located in the vicinity of taste buds. Some taste bud cells were also immoureactive for the calcium-binding protein (CaBP). In the carotid body, however, OC-IR nerve fibers could not be detected. Retrograde tracing with fluorogold revealed that OC-IR nerve fibers in the circumvallate papilla mainly originated from the petrosal ganglion. These findings may suggest that OC-IR petrosal neurons have chemoreceptive function in the tongue.
AB - Immunohistochemistry for osteocalcin (OC) was performed on the rat vagal and glossopharyngeal sensory ganglia. OC-immunoreactive (IR) neurons were detected in the jugular (10%), petrosal (11%) and nodose ganglia (6%). The cell size analysis demonstrated that OC-IR neurons were predominantly small to medium-sized in the jugular ganglion (mean±S.D.=356.3±192.2 μm 2, range=86.5-831.5 μm 2). On the other hand, such neurons were medium-sized to large in the petrosal (mean±S.D.=725. 6±280.7 μm 2, range=124.7-1540.4 μm 2) and nodose ganglia (mean±S.D.=857.5±330.2 μm 2, range=367.1-1608.0 μm 2). In the circumvallate papilla, OC-IR nerve fibers were located in the vicinity of taste buds. Some taste bud cells were also immoureactive for the calcium-binding protein (CaBP). In the carotid body, however, OC-IR nerve fibers could not be detected. Retrograde tracing with fluorogold revealed that OC-IR nerve fibers in the circumvallate papilla mainly originated from the petrosal ganglion. These findings may suggest that OC-IR petrosal neurons have chemoreceptive function in the tongue.
KW - Immunohistochemistry
KW - Jugular ganglion
KW - Nodose ganglion
KW - Osteocalcin
KW - Petrosal ganglion
KW - Taste bud
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U2 - 10.1016/j.brainres.2004.10.011
DO - 10.1016/j.brainres.2004.10.011
M3 - Article
C2 - 15621021
AN - SCOPUS:11144296910
SN - 0006-8993
VL - 1031
SP - 129
EP - 133
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1
ER -