Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis

Kenichi Harimoto, Yasuhiro Yoshida, Kumiko Yoshihara, Noriyuki Nagaoka, Takuya Matsumoto, Yoh Ichi Tagawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Titanium has an osseointegrative property, while hydroxyapatite has an osteoconductive property. It remains a matter of controversy among researchers whether hydroxyapatite has higher osteoblast compatibility than titanium. Here, we compared the activities between osteoblasts cultured on titanium and those cultured on hydroxyapatite. An osteoblast-like cell line, MC3T3-E1, was cultured on machined titanium, evaporated titanium, and hydroxyapatite disks to compare the affinity of osteoblasts to each of these materials. The adhesion and proliferation of MC3T3-E1 cells were higher on hydroxyapatite disks than on the other disks. Osteoblast differentiation was not affected by the nature of disks investigated, but calcium was more easily deposited on the hydroxyapatite disks. The amount of absorbed serum proteins detected on hydroxyapatite was greater than that on titanium. In conclusion, our results indicate hydroxyapatite is a more suitable material for osteoblast growth than titanium because of its higher absorption of serum proteins.

Original languageEnglish
Pages (from-to)674-680
Number of pages7
JournalDental Materials Journal
Volume31
Issue number4
DOIs
Publication statusPublished - 2012

Fingerprint

Osteoblasts
Durapatite
Hydroxyapatite
Osteogenesis
Titanium
Blood Proteins
Proteins
Calcium
Adhesion
Cells
Research Personnel
Cell Line
Growth

Keywords

  • Hydroxyapatite
  • Osteoblast
  • Titanium

ASJC Scopus subject areas

  • Dentistry(all)
  • Ceramics and Composites

Cite this

Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis. / Harimoto, Kenichi; Yoshida, Yasuhiro; Yoshihara, Kumiko; Nagaoka, Noriyuki; Matsumoto, Takuya; Tagawa, Yoh Ichi.

In: Dental Materials Journal, Vol. 31, No. 4, 2012, p. 674-680.

Research output: Contribution to journalArticle

Harimoto, Kenichi ; Yoshida, Yasuhiro ; Yoshihara, Kumiko ; Nagaoka, Noriyuki ; Matsumoto, Takuya ; Tagawa, Yoh Ichi. / Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis. In: Dental Materials Journal. 2012 ; Vol. 31, No. 4. pp. 674-680.
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