Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)

S. D. McCormick, Tatsuya Sakamoto, S. Hasegawa, T. Hirano

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0.2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0.01, 0.05 and 0.2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0.01, 0.05 and 0.2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalJournal of Endocrinology
Volume130
Issue number1
DOIs
Publication statusPublished - Jan 1 1991
Externally publishedYes

Fingerprint

Oncorhynchus mykiss
Seawater
Insulin-Like Growth Factor I
Osmolar Concentration
Ions
Insulin
Trout
Action Potentials
Sheep
Fishes
Sodium
Hormones
Glucose
Injections

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss). / McCormick, S. D.; Sakamoto, Tatsuya; Hasegawa, S.; Hirano, T.

In: Journal of Endocrinology, Vol. 130, No. 1, 01.01.1991, p. 87-92.

Research output: Contribution to journalArticle

@article{32a9d342d1f045b580177a159db326ae,
title = "Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)",
abstract = "The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0.2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0.01, 0.05 and 0.2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0.01, 0.05 and 0.2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater",
author = "McCormick, {S. D.} and Tatsuya Sakamoto and S. Hasegawa and T. Hirano",
year = "1991",
month = "1",
day = "1",
doi = "10.1677/joe.0.1300087",
language = "English",
volume = "130",
pages = "87--92",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "Society for Endocrinology",
number = "1",

}

TY - JOUR

T1 - Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)

AU - McCormick, S. D.

AU - Sakamoto, Tatsuya

AU - Hasegawa, S.

AU - Hirano, T.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0.2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0.01, 0.05 and 0.2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0.01, 0.05 and 0.2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater

AB - The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0.2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0.01, 0.05 and 0.2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0.01, 0.05 and 0.2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater

UR - http://www.scopus.com/inward/record.url?scp=0025783732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025783732&partnerID=8YFLogxK

U2 - 10.1677/joe.0.1300087

DO - 10.1677/joe.0.1300087

M3 - Article

VL - 130

SP - 87

EP - 92

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

IS - 1

ER -